Home MAPK -ER stress & UPR JNK JNK2 Inhibitors

JNK2 Inhibitors

  • JNK1
  • JNK2
  • JNK3
Kat.-Nr. Produktname Informationen Selektiv / Pan IC50 / Ki
S4901 JNK-IN-8 JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβ. Pan JNK2, IC50: 18.7 nM
S1460 SP600125 SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. Pan JNK2, IC50: 40 nM
S7508 JNK Inhibitor IX JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. Pan JNK2, pIC50: 6.5