Home Protein Tyrosine Kinase -Neuronal Signaling Trk receptor TrkB-selektive Inhibitors | Antagonists

TrkB-selektive Inhibitors | Antagonists

  • TrkA
  • TrkB
  • TrkC
Kat.-Nr. Produktname Informationen Selektiv / Pan IC50 / Ki
S7745 ANA-12 ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively. Selective TrkB, Kd: 10 nM
S1124 BMS-754807 BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2. Pan TrkB, IC50: 4.1 nM
S7519 GNF-5837 GNF-5837 is a selective, and orally bioavailable pan-TRK inhibitor for TrkA, and TrkB with IC50 of 8 nM, and 12 nM, respectively. Pan TrkB, IC50: 9 nM