Home Cell Cycle Chk Chk1-selektive Inhibitors

Chk1-selektive Inhibitors

  • Chk1
  • Chk2
Kat.-Nr. Produktname Informationen Selektiv / Pan IC50 / Ki
S2683 CHIR-124 CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2. Selective Chk1, IC50: 0.3 nM
S2904 PF-477736 PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2. Phase 1. Selective Chk1, Ki: 0.49 nM
S2735 MK-8776 (SCH 900776) SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 500-fold selectivity against Chk2. Phase 2. Selective Chk1, IC50: 3 nM
S2626 LY2603618 LY2603618 is a selective Chk1 inhibitor with potential anti-tumor activity. Phase 2. Selective
S1532 AZD7762 AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1. Pan Chk1, IC50: 5 nM