Home Apoptosis -DNA Damage/DNA Repair MDM2/MDMX Mdm2-selektive Inhibitors | Antagonists

Mdm2-selektive Inhibitors | Antagonists

  • MDM2
  • MDMX
Kat.-Nr. Produktname Informationen Selektiv / Pan IC50 / Ki
S7649 MI-773 (SAR405838) MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. Selective MDM2, IC50: 0.88 nM
S8059 Nutlin-3a Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM. Selective p53/MDM2 interaction, IC50: 90 nM
S1061 Nutlin-3 Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM; stabilizes p73 in p53-deficient cells. Selective Mdm2, IC50: 90 nM
S8065 Nutlin-3b Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. Selective Mdm2, IC50: 13.6 μM
S7489 YH239-EE YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. Selective