Home Metabolism PDE PDE5-selektive Inhibitors

PDE5-selektive Inhibitors

  • PDE1
  • PDE2
  • PDE3
  • PDE4
  • PDE5
  • PDE6
  • PDE10A
Kat.-Nr. Produktname Informationen Selektiv / Pan IC50 / Ki
S2515 Vardenafil HCl Trihydrate Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. Selective PDE5, IC50: 0.7 nM
S4019 Avanafil Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs. Selective PDE5, IC50: 1 nM
S1512 Tadalafil Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. Selective PDE5, IC50: 1.8 nM
S2312 Icariin Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4. Selective PDE5, IC50: 0.432 μM
S1431 Sildenafil Citrate Sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction. Pan PDE5, IC50: 3.5 nM
S2320 Luteolin Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2. Pan PDE5, Ki: 9.5 μM