SIRT1-selektive Inhibitors | Activators
- SIRT1
- SIRT2
- SIRT3
| Kat.-Nr. | Produktname | Informationen | Selektiv / Pan | IC50 / Ki |
|---|---|---|---|---|
| S1541 | EX 527 (Selisistat) | EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3. | Selective | SIRT1, IC50: 38 nM |
| S1129 | SRT1720 | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3. | Selective | SIRT1, EC50: 0.16 μM |
| S4900 | Tenovin-6 | Tenovin-6 is a small molecule activator of p53 transcriptional activity. | Pan | SIRT1, IC50: 21 μM |
| S2804 | Sirtinol | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. | Pan | SIRT1, IC50: 131 μM |
| S1396 | Resveratrol | Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. | Pan |
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