Home GPCR & G Protein S1P Receptor SphK-selektive Inhibitors

SphK-selektive Inhibitors

  • S1PR1
  • S1PR4
  • S1PR5
  • SphK
Kat.-Nr. Produktname Informationen Selektiv / Pan IC50 / Ki
S7177 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. Selective SphK1, Ki: 3.6 nM; SphK1, IC50: 2.0 nM