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APC Inhibitoren (APC Inhibitors)

Anaphase-Promoting Complex (APC) which is also called cyclosome, a highly conserved protein, plays a key role in both cell cycle and Ubq degradation pathway. The APC can results in degradation of specific proteins which are involved in cell cycle by tagging those proteins during the transition from metaphase to anaphase. When spindle checkpoint is silenced, APC can easily bind to Cdc20 after phosphorylated by M-Cdks. Then APC targets cyclin A and cyclin B for degradation.

Weitere Cell Cycle Inhibitoren

CDK ROCK Wee1 Aurora Kinase Chk PLK MPS1 Rho Myc DYRK
Kat.-Nr. Produktname Informationen Publikationen Validierung
S2225 TAME Tosyl-L-Arginin-Methylester (TAME) ist ein APC-Inhibitor.
Dev Cell, 2023, 58(3):192-210.e11
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
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S9605 Apcin Apcin (APC-Inhibitor) ist ein Inhibitor der E3-Ligase-Aktivität des mitotischen Anaphase-promoting complex/cycloms (APC/C), der an Cdc20 bindet und die Ubiquitinierung von D-Box-haltigen Substraten kompetitiv hemmt.
Nature, 2025, 647(8091):952-961
Theranostics, 2025, 15(8):3439-3461
Cell Mol Biol Lett, 2025, 30(1):29