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Perifosine Akt Inhibitor

Name: Perifosine
Brand: Selleck Chemicals
SKU: S1037
Rating: 5 (170 reviews)

Kat.-Nr.: S1037

Perifosine ist ein neuartiger Akt-Inhibitor mit einem IC50-Wert von 4,7 μM in MM.1S-Zellen und zielt auf die Pleckstrin-Homologie-Domäne von Akt ab. Phase 3.

Perifosine Akt Inhibitor Chemical Structure

Chemische Struktur

Molekulargewicht: 461.66

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Qualitätskontrolle (Quality Control)

Charge: Reinheit: >97.00%

Zitiert in Nature Medicine für seine erstklassige Qualität
COA
NMR
Mikroanalyse

Warum Mikroanalyse?
Datenblatt
SDS

Zitiert in Nature Medicine für seine erstklassige Qualität
COA
NMR
Datenblatt
SDS

Zitiert in Nature Medicine für seine erstklassige Qualität
COA
NMR
Datenblatt
SDS

Zitiert in Nature Medicine für seine erstklassige Qualität
COA
NMR
Datenblatt
SDS

Zitiert in Nature Medicine für seine erstklassige Qualität
COA
NMR
Datenblatt
SDS

97.00

Verwandte Ziele	PI3K mTOR GSK-3 ATM/ATR DNA-PK AMPK PDPK1 PTEN PP2A PDK
Weitere Akt Inhibitoren	SC79 AZD5363 (Capivasertib) MK-2206 Dihydrochloride Ipatasertib (GDC-0068) GSK690693 Triciribine (API-2) Afuresertib (GSK2110183) CCT128930 A-674563 HCl AKTi-1/2 (AKT Inhibitor VIII)

Zellkultur, Behandlung & Arbeitskonzentration
(Cell Culture, Treatment & Working Concentration)

Zelllinien	Assay-Typ	Konzentration	Inkubationszeit	Aktivitätsbeschreibung	PMID
HL-60	Apoptosis Asssay	10 μM	24/48 h	induces apoptosis time-dependently	20130960
MOLM	Apoptosis Asssay	10 μM	24/48 h	induces apoptosis time-dependently	20130960
OCI	Apoptosis Asssay	10 μM	24/48 h	induces apoptosis time-dependently	20130960
BJAB	Apoptosis Asssay	10 μM	24/48 h	induces apoptosis time-dependently	20130960
MAVER	Apoptosis Asssay	10 μM	24/48 h	induces apoptosis time-dependently	20130960
SKW6.4	Apoptosis Asssay	10 μM	24/48 h	induces apoptosis time-dependently	20130960
HL-60	Growth Inhibition Assay	2-10 μM	48 h	inhibits cell growth in a dose dependent manner	20130960
MOLM	Growth Inhibition Assay	2-10 μM	48 h	inhibits cell growth in a dose dependent manner	20130960
OCI	Growth Inhibition Assay	2-10 μM	48 h	inhibits cell growth in a dose dependent manner	20130960
BJAB	Growth Inhibition Assay	2-10 μM	48 h	inhibits cell growth in a dose dependent manner	20130960
MAVER	Growth Inhibition Assay	2-10 μM	48 h	inhibits cell growth in a dose dependent manner	20130960
SKW6.4	Growth Inhibition Assay	2-10 μM	48 h	inhibits cell growth in a dose dependent manner	20130960
A2780cis	Growth Inhibition Assay	0-20 μM	48/72 h	IC50 = 6 μm	20405296
A2780	Growth Inhibition Assay	0-20 μM	48/72 h	IC50 = 3 μm	20405296
SKOV3	Growth Inhibition Assay	0-40 μM	72 h	IC50~30 μM, inhibits cell growth in a dose dependent manner	20405296
PA-1	Growth Inhibition Assay	0-40 μM	72 h	IC50~25 μM, inhibits cell growth in a dose dependent manner	20405296
OAW-42	Growth Inhibition Assay	0-40 μM	72 h	IC50~10 μM, inhibits cell growth in a dose dependent manner	20405296
Bel-7402	Apoptosis Asssay	5/10/20 μM	24/48 h	induces apoptosis at the long-time exposure	20842425
HepG2	Apoptosis Asssay	5/10/20 μM	24/48 h	induces apoptosis at the long-time exposure	20842425
Bel-7402	Function Assay	5/10/20 μM	24 h	results in the accumulation of cell number in the G2/M phase	20842425
HepG2	Function Assay	5/10/20 μM	24 h	results in the accumulation of cell number in the G2/M phase	20842425
Bel-7402	Growth Inhibition Assay	5/10/20/40 μM	24/48/72 h	inhibits cell growth in both time and dose dependent manner	20842425
HepG2	Growth Inhibition Assay	5/10/20/40 μM	24/48/72 h	inhibits cell growth in both time and dose dependent manner	20842425
CWR22RV1	Function Assay	5 μM	24 h	reduced phosphorylation of Akt significantly	21496273
CWR22RV1	Apoptosis Asssay	10 μM	24 h	enhances radiation induced apoptosis	21496273
CWR22RV1	Cell Viability Assay	10 μM	24 h	increases sensitivity of human CWR22RV1 cells to radiation	21496273
A498	Growth Inhibition Assay	0-20 μM	72 h	inhibits cell growth in a dose dependent manner	21644050
769-P	Growth Inhibition Assay	0-20 μM	72 h	inhibits cell growth in a dose dependent manner	21644050
CAKI-1	Growth Inhibition Assay	0-20 μM	72 h	inhibits cell growth in a dose dependent manner	21644050
786-O	Growth Inhibition Assay	0-20 μM	72 h	inhibits cell growth in a dose dependent manner	21644050
786-0	Growth Inhibition Assay	0-40 μM	72 h	IC50~5 μM	21644050
769-P	Growth Inhibition Assay	0-40 μM	72 h	IC50~5-10 μM	21644050
CAKI-1	Growth Inhibition Assay	0-40 μM	72 h	IC50~10 μM	21644050
A498	Growth Inhibition Assay	0-40 μM	72 h	inhibits cell growth in a dose dependent manner	21644050
HT-29	Cytotoxicity Assay	5 μM	48 h	enhances paclitaxel induced ovarian cancer cell death	21775054
A2780	Cytotoxicity Assay	5 μM	48 h	enhances paclitaxel induced ovarian cancer cell death	21775054
SKOV3	Cytotoxicity Assay	5 μM	48 h	enhances paclitaxel induced ovarian cancer cell death	21775054
CaOV3	Cell Viability Assay	1/5/10 μM	48 h	decreases cell viability in a dose dependent manner cotreated with paclitaxel	21775054
OCUT1	Function Assay	3 μm	24 h	causes a dramatic increase in G2/M phase	22090271
K1	Growth Inhibition Assay	0.1-3 μM	5 d	inhibits cell growth in a dose dependent manner	22090271
OCUT1	Growth Inhibition Assay	0.1-3 μM	5 d	inhibits cell growth in a dose dependent manner	22090271
K562	Function Assay	20 μM	48 h	induces autophagy	22407228
HL-60	Function Assay	2.5/5/10 μM	24 h	induces the phosphorylation of JNK1/2 in a dose dependent manner	22407228
Kasumi-1	Function Assay	2.5/5/10 μM	24 h	induces the phosphorylation of JNK1/2 in a dose dependent manner	22407228
HL-60	Function Assay	2.5/5/10 μM	24 h	decreases Akt and p-Akt levels dose-dependently	22407228
Kasumi-1	Function Assay	2.5/5/10 μM	24 h	decreases Akt and p-Akt levels dose-dependently	22407228
HL-60	Apoptosis Asssay	10 μM	24 h	induces apoptosis	22407228
Kasumi-1	Apoptosis Asssay	10 μM	24 h	induces apoptosis	22407228
HL-60	Cell Viability Assay	0-20 μM	24/48 h	decreases cell viability in both dose and time dependent manner	22407228
Kasumi-1	Cell Viability Assay	0-20 μM	24/48 h	decreases cell viability in both dose and time dependent manner	22407228
BON1	Function Assay	7.5/10 μM	8 h	decreases the expression of the anti-apoptotic proteins BCL2 and Bcl-XL	22499437
BON1	Apoptosis Asssay	0-10 μM	24 h	induces apoptosis dose dependently	22499437
BON1	Cell Viability Assay	0-100 μM	24/72 h	decreases cell viability in both dose and time dependent manner	22499437
GOT1	Cell Viability Assay	0-100 μM	24/72 h	decreases cell viability in both dose and time dependent manner	22499437
NCI-H727	Cell Viability Assay	0-100 μM	24/72 h	decreases cell viability in both dose and time dependent manner	22499437
MCAS	Growth Inhibition Assay			IC50=12.5 μM	23877012
A2780S	Growth Inhibition Assay			IC50=14.5 μM	23877012
OVCAR5	Growth Inhibition Assay			IC50=6.7 μM	23877012
A2780CP	Growth Inhibition Assay			IC50=7.6 μM	23877012
HeyA8	Growth Inhibition Assay			IC50=24.3 μM	23877012
OVCAR8	Growth Inhibition Assay			IC50=31.1 μM	23877012
M41R	Growth Inhibition Assay			IC50=19.8 μM	23877012
M41	Growth Inhibition Assay			IC50=24.7 μM	23877012
TykNuR	Growth Inhibition Assay			IC50=5.5 μM	23877012
TykNu	Growth Inhibition Assay			IC50=3.5 μM	23877012
MGC803	Function Assay	0.75/10 μM	48 h	decreases p-Akt (Ser 473), p-GSK3β (Ser 9), and C-MYC levels	23912246
SGC7901	Function Assay	0.75/10 μM	48 h	decreases p-Akt (Ser 473), p-GSK3β (Ser 9), and C-MYC levels	23912246
U87MG	Cell Viability Assay	0-25 μM	24-96 h	decreases cell viability in both dose and time dependent manner	24065522
AsPC-1	Function Assay	0.5 μM	24 h	inhibits Akt, S6K1, and Erk1/2 phosphorylation	24519751
MIA	Function Assay	0.5 μM	24 h	inhibits Akt, S6K1, and Erk1/2 phosphorylation	24519751
PANC-1	Function Assay	0.5 μM	24 h	inhibits Akt, S6K1, and Erk1/2 phosphorylation	24519751
AsPC-1	Growth Inhibition Assay	0-25 μM	72 h	inhibits cell growth in a dose dependent manner	24519751
MIA	Growth Inhibition Assay	0-25 μM	72 h	inhibits cell growth in a dose dependent manner	24519751
PANC-1	Growth Inhibition Assay	0-25 μM	72 h	inhibits cell growth in a dose dependent manner	24519751
Ema	Growth Inhibition Assay	0.1–100 μM	48 h	IC50=58.7 μM	24881508
UL-1	Growth Inhibition Assay	0.1–100 μM	48 h	IC50=7.01 μM	24881508
CLBL-1	Growth Inhibition Assay	0.1–100 μM	48 h	IC50=33.0 μM	24881508
GL-1	Growth Inhibition Assay	0.1–100 μM	48 h	IC50=9.91 μM	24881508
MDA-MB-231	Growth Inhibition Assay	0-10 μM	48 h	EC50=1.13 ± 0.07 μM	25293576
HCC1806	Growth Inhibition Assay	0-10 μM	48 h	EC50=2.84 ± 0.07 μM	25293576
RMG2	Apoptosis Asssay	30 μM	24 h	induces apoptosis	25519148
RMG1	Apoptosis Asssay	30 μM	24 h	induces apoptosis	25519148
A2780	Cell Viability Assay	1-30 μM	48 h	decreases cell viability in a dose dependent manner	25519148
SKOV3	Cell Viability Assay	1-30 μM	48 h	decreases cell viability in a dose dependent manner	25519148
OVISE	Cell Viability Assay	1-30 μM	48 h	decreases cell viability in a dose dependent manner	25519148
RMG2	Cell Viability Assay	1-30 μM	48 h	decreases cell viability in a dose dependent manner	25519148
HAC2	Cell Viability Assay	1-30 μM	72 h	decreases cell viability in a dose dependent manner	25519148
KOC7C	Cell Viability Assay	1-30 μM	72 h	decreases cell viability in a dose dependent manner	25519148
RMG2	Cell Viability Assay	1-30 μM	72 h	decreases cell viability in a dose dependent manner	25519148
RMG1	Cell Viability Assay	1-30 μM	72 h	decreases cell viability in a dose dependent manner	25519148
H460	Function Assay	3 μM	8 h	blocks mTORC1, and ERK-MAPK activation combined with MEK-162	25697899
A549	Function Assay	3 μM	8 h	blocks mTORC1, and ERK-MAPK activation combined with MEK-162	25697899
H460	Function Assay	3 μM	8 h	blocks AKT activation	25697899
A549	Function Assay	3 μM	8 h	blocks AKT activation	25697899
H460	Apoptosis Asssay	1/3 μM	48 h	induces apoptosis	25697899
A549	Apoptosis Asssay	1/3 μM	48 h	induces apoptosis	25697899
H460	Growth Inhibition Assay	0.3-10 μM	24/72 h	inhibits cell growth in both time and dose dependent manner	25697899
A549	Growth Inhibition Assay	0.3-10 μM	24/72 h	inhibits cell growth in both time and dose dependent manner	25697899
U-87 MG	Growth Inhibition Assay	20/40 μM	24/48 h	inhibits cell growth in both time and dose dependent manner	25934232
HepG2	Growth Inhibition Assay	20/40 μM	24/48 h	inhibits cell growth in both time and dose dependent manner	25934232
U-87 MG	Function Assay	20 μM	6/24 h	increases the autophagic flux at 6 h while inhibits this flux at 24h	25934232
HepG2	Function Assay	20 μM	6/24 h	decreases LC3-II degradation from 6 h	25934232
U-87 MG	Function Assay	20 μM	6/24 h	increases the levels of LC3-II cotreated with CQ	25934232
HepG2	Function Assay	20 μM	6/24 h	increases the levels of LC3-II cotreated with CQ	25934232
U-87 MG	Function Assay	20 μM	24 h	increases double-membrane bound structures	25934232
HepG2	Function Assay	20 μM	24 h	produces an intense cytoplasmic vacuolization corresponding to a notable dilatation of the ER cisterns	25934232
T24 BC	Apoptosis Asssay	2.5 μM	24 h	sensitizes BC cells to sorafenib-induced apoptotic	26097873
T24 BC	Cell Viability Assay	0.5/1/2.5 μM	24 h	enhances sorafenib-induced cell viability decrease	26097873
T24 BC	Function Assay	0.5/1/2.5 μM	3 h	reduces the basal CB tyrosine phosphorylation levels in a dose-dependent manner	26097873
RBL2H3	Function assay			Toxicity in rat RBL2H3 cells, MTD=25μM	20153565
PC3	Growth inhibition assay			Growth inhibition of human PC3 cells by sulforhodamine B assay, GI50=0.44μM	21543141
NUGC3	Growth inhibition assay			Growth inhibition of human NUGC3 cells by sulforhodamine B assay, GI50=0.54μM	21543141
HCT15	Growth inhibition assay			Growth inhibition of human HCT15 cells by sulforhodamine B assay, GI50=1.25μM	21543141
MDA-MB-231	Growth inhibition assay			Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay, GI50=2.86μM	21543141
NCI-H23	Growth inhibition assay			Growth inhibition of human NCI-H23 cells by sulforhodamine B assay, GI50=4.21μM	21543141
ACHN	Growth inhibition assay			Growth inhibition of human ACHN cells by sulforhodamine B assay, GI50=4.56μM	21543141
A549	Function assay		30 mins	Inhibition of Akt phosphorylation in insulin-stimulated human A549 cells treated 2 hrs before insulin stimulation measured after 30 mins by ELISA, IC50=5.3μM	22138309
A549	Cytotoxicity assay		24 hrs	Cytotoxicity against human A549 cells after 24 hrs by FACS analysis, IC50=7μM	22138309
KATO III	Cytotoxicity assay		24 hrs	Cytotoxicity against human KATO III cells after 24 hrs by FACS analysis, IC50=12.8μM	22138309
MCF7	Cytotoxicity assay		24 hrs	Cytotoxicity against human MCF7 cells after 24 hrs by FACS analysis, IC50=13.3μM	22138309
PC3	Growth inhibition assay			Growth inhibition of human PC3 cells by SRB assay, GI50=0.44μM	23266181
NUGC3	Growth inhibition assay			Growth inhibition of human NUGC3 cells by SRB assay, GI50=0.54μM	23266181
HCT15	Growth inhibition assay			Growth inhibition of human HCT15 cells by SRB assay, GI50=1.25μM	23266181
MDA-MB-231	Growth inhibition assay			Growth inhibition of human MDA-MB-231 cells by SRB assay, GI50=2.86μM	23266181
NCI-H23	Growth inhibition assay			Growth inhibition of human NCI-H23 cells by SRB assay, GI50=4.21μM	23266181
ACHN	Growth inhibition assay			Growth inhibition of human ACHN cells by SRB assay, GI50=4.56μM	23266181
A549	Function assay		2 hrs	Inhibition of Akt phosphorylation in human insulin-stimulated A549 cells incubated for 2 hrs prior to insulin-induction measured after 30 mins by ELISA, IC50=5.3μM	23415083
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by flow cytometric analysis, IC50=7μM	23415083
KATO III	Cytotoxicity assay			Cytotoxicity against human KATO III cells by flow cytometric analysis, IC50=12.8μM	23415083
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by flow cytometric analysis, IC50=13.3μM	23415083
PC3	Antiproliferative assay			Antiproliferative activity against human PC3 cells by SRB assay, GI50=0.44μM	23567950
NUGC3	Antiproliferative assay			Antiproliferative activity against human NUGC3 cells by SRB assay, GI50=0.54μM	23567950
HCT15	Antiproliferative assay			Antiproliferative activity against human HCT15 cells by SRB assay, GI50=1.25μM	23567950
MDA-MB-231	Antiproliferative assay			Antiproliferative activity against human MDA-MB-231 cells by SRB assay, GI50=2.86μM	23567950
NCI-H23	Antiproliferative assay			Antiproliferative activity against human NCI-H23 cells by SRB assay, GI50=4.21μM	23567950
ACHN	Antiproliferative assay			Antiproliferative activity against human ACHN cells by SRB assay, GI50=4.56μM	23567950
PC3	Growth inhibition assay		48 hrs	Growth inhibition of human PC3 cells after 48 hrs by SRB assay, GI50=0.44μM	24095759
NUGC3	Growth inhibition assay		48 hrs	Growth inhibition of human NUGC3 cells after 48 hrs by SRB assay, GI50=0.54μM	24095759
HCT15	Growth inhibition assay		48 hrs	Growth inhibition of human HCT15 cells after 48 hrs by SRB assay, GI50=1.25μM	24095759
MDA-MB-231	Growth inhibition assay		48 hrs	Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay, GI50=2.86μM	24095759
NCI-H23	Growth inhibition assay		48 hrs	Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay, GI50=4.21μM	24095759
ACHN	Growth inhibition assay		48 hrs	Growth inhibition of human ACHN cells after 48 hrs by SRB assay, GI50=4.56μM	24095759
A549	Cytotoxicity assay		24 to 72 hrs	Cytotoxicity against human A549 cells after 24 to 72 hrs by haemocytometry, IC50=4.17μM	24900620
Rosetta cells	Function assay			Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cells, IC50=1.2μM	31274316
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Chemische Informationen, Lagerung & Stabilität (Chemical Information, Storage & Stability)

Molekulargewicht	461.66	Formel	C₂₅H₅₂NO₄P	Lagerung (Ab dem Eingangsdatum)	3 Jahre-20°CPulver
CAS-Nr.	157716-52-4	SDF herunterladen		Lagerung von Stammlösungen	1 Jahr-80°Cin Lösungsmittel 1 Monat-20°Cin Lösungsmittel
Synonyme	KRX-0401, NSC639966, D21266			Smiles	CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

Löslichkeit (Solubility)

In vitro
Charge:

Water : 92 mg/mL

Ethanol : 92 mg/mL

DMSO : Insoluble
(Feuchtigkeitskontaminiertes DMSO kann die Löslichkeit verringern. Verwenden Sie frisches, wasserfreies DMSO.)

Molaritätsrechner

Masse	Konzentration	Volumen	Molekulargewicht
=	×	×

Verdünnungsrechner Molekulargewichtsrechner

In vivo Charge:
Clear solution	water Von Selleck Labs validiert. Sollten Sie Anpassungen an dieser Formulierung benötigen, kontaktieren Sie unser Verkaufsteam für kundenspezifische Tests.	8.000mg/ml (17.33mM)	Taking the 1 mL working solution as an example, add 8 mg of this product to 1 ml of ddH2O, mix evenly to make it clear, The mixed solution should be used immediately for optimal results.

In-vivo-Formulierungsrechner (Klare Lösung)

Schritt 1: Geben Sie die untenstehenden Informationen ein (Empfohlen: Ein zusätzliches Tier zur Berücksichtigung von Verlusten während des Experiments)

Dosierung: mg/kg Durchschnittsgewicht der Tiere: g Dosiervolumen pro Tier:μL Anzahl der Tiere:

Schritt 2: Geben Sie die In-vivo-Formulierung ein (Dies ist nur der Rechner, keine Formulierung. Bitte kontaktieren Sie uns zuerst, wenn es im Abschnitt "Löslichkeit" keine In-vivo-Formulierung gibt.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Berechnungsergebnisse:

Arbeitskonzentration: mg/ml;

Methode zur Herstellung der DMSO-Stammlösung: mg Wirkstoff vorgelöst in μL DMSO ( Konzentration der Stammlösung mg/mL, Bitte kontaktieren Sie uns zuerst, wenn die Konzentration die DMSO-Löslichkeit der Wirkstoffcharge überschreitet. )

Methode zur Herstellung der In-vivo-Formulierung: Nehmen Sie μL DMSO Stammlösung, dann hinzufügenμL PEG300, mischen und klären, dann hinzufügenμL Tween 80, mischen und klären, dann hinzufügen μL ddH₂O, mischen und klären.

Methode zur Herstellung der In-vivo-Formulierung: Nehmen Sie μL DMSO Stammlösung, dann hinzufügen μL Maisöl, mischen und klären.

Hinweis: 1. Bitte stellen Sie sicher, dass die Flüssigkeit klar ist, bevor Sie das nächste Lösungsmittel hinzufügen.
2. Achten Sie darauf, das/die Lösungsmittel der Reihe nach hinzuzufügen. Sie müssen sicherstellen, dass die bei der vorherigen Zugabe erhaltene Lösung eine klare Lösung ist, bevor Sie mit der Zugabe des nächsten Lösungsmittels fortfahren. Physikalische Methoden wie Vortex, Ultraschall oder ein heißes Wasserbad können zur Unterstützung des Lösens verwendet werden.

Wirkmechanismus (Mechanism of Action)

Targets/IC₅₀/Ki	Akt (MM.1S cells) 4.7 μM
In vitro	Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. This compound strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. It completely inhibits the phosphorylation of Akt in MM.1S cells. A recent study demonstrates this chemical induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation.
Kinase-Assay	Akt-Kinase-Assay
Kinase-Assay	MM.1S-Zellen werden in An- oder Abwesenheit von Perifosine (5 μM, 6 Stunden) kultiviert und anschließend mit IL-6 (20 ng/mL, 10 Minuten) stimuliert. Ein In-vitro-Akt-Kinase-Assay wird dann unter Verwendung des Akt Kinase Assay Kits durchgeführt.
In vivo	Perifosine in combination reduces tumor proliferation (a PDGF-driven gliomagenesis) in vivo. The results indicate that this compound is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be new candidate for glima treatment in the clinic. Both oral daily and weekly administration of this chemical significantly reduce human MM tumor growth and increase survival, compared with control animals treated with PBS vehicle only. It induces thrombocytosis and leukocytosis and increases myelopoiesis in murine marrow and spleen, whereas it causes apoptosis in myeloma xenografts.
Literatur	[1] https://pubmed.ncbi.nlm.nih.gov/11888912/ [2] http://www.ncbi.nlm.nih.gov/pubmed?term=16103096 [3] http://www.ncbi.nlm.nih.gov/pubmed?term=16418332%20 [4] https://pubmed.ncbi.nlm.nih.gov/20842425/ [5] https://pubmed.ncbi.nlm.nih.gov/17588472/

Anwendungen (Applications)

Methoden	Biomarker	Bilder	PMID
Western blot	p-AKT / AKT / p-S6K1 / S6K1 PARP p-mTOR / mTOR / Raptor / Rictor / p-p70S6K / p70S6K / p-4EBP1 / 4EBP1 / c-Myc / Cyclin D1 p-PDK1 / p-GSK3α/β / p-S6R		25519148
Growth inhibition assay	Cell viability		28332584

Klinische Studieninformationen (Clinical Trial Information)

(Daten von https://clinicaltrials.gov, aktualisiert am 2024-05-22)

NCT-Nummer	Rekrutierung	Erkrankungen	Sponsor/Kooperationspartner	Startdatum	Phasen
NCT01224730	Completed	Cancer	AEterna Zentaris	January 24 2012	Phase 1
NCT01049841	Completed	Pediatric Solid Tumors	Memorial Sloan Kettering Cancer Center\|University of Wisconsin Madison\|Duke University\|NATL COMP CA NETWORK\|Pfizer\|AEterna Zentaris	January 2010	Phase 1
NCT01048580	Completed	Colon Cancer	AEterna Zentaris\|SCRI Development Innovations LLC	October 2009	Phase 1
NCT00776867	Completed	Solid Tumors	Memorial Sloan Kettering Cancer Center\|University of Wisconsin Madison\|Duke University\|AEterna Zentaris	October 2008	Phase 1

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):