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Ponatinib (AP24534) Bcr-Abl Inhibitor
Kat.-Nr.S1490
Chemische Struktur
Molekulargewicht: 532.56
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Qualitätskontrolle
Charge:
Reinheit:
99.75%
99.75
Zellkultur, Behandlung & Arbeitskonzentration
| Zelllinien | Assay-Typ | Konzentration | Inkubationszeit | Formulierung | Aktivitätsbeschreibung | PMID |
|---|---|---|---|---|---|---|
| EoL-1-cell | Growth Inhibition Assay | IC50=0.0000000359 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.0000956 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.000128 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.000165 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | |||
| KASUMI-1 | Growth Inhibition Assay | IC50=0.00217 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.00259 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.00521 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.00655 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.00837 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.01218 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=0.01833 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.01873 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=0.02199 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=0.02537 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.02848 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.03294 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.04803 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.05448 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=0.05576 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.06341 μM | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | IC50=0.06379 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=0.07888 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.0906 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.09737 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=0.09982 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=0.11336 μM | SANGER | |||
| MFE-296 | Growth Inhibition Assay | IC50=0.11839 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.12443 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=0.12512 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=0.1337 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.15672 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=0.16266 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.16933 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.17063 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.17316 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=0.17489 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.17732 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.17927 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.18577 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.18871 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=0.19287 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.19318 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.19615 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.20439 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=0.20873 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=0.21069 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.21666 μM | SANGER | |||
| CCF-STTG1 | Growth Inhibition Assay | IC50=0.22475 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.23177 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.23795 μM | SANGER | |||
| MES-SA | Growth Inhibition Assay | IC50=0.24187 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.24265 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.24367 μM | SANGER | |||
| NALM-6 | Growth Inhibition Assay | IC50=0.25543 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=0.26091 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.26228 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=0.26829 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.26891 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=0.26974 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.27264 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=0.27329 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=0.27763 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=0.28303 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.28419 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.29323 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.29353 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.29577 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=0.29964 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.29978 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=0.30411 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.31164 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.3128 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.31453 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.31466 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.31484 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.33368 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.33424 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.34304 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.34873 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=0.34989 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=0.36001 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.36106 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.36455 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=0.36473 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.38054 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.39791 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.39793 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.41586 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=0.4186 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.42137 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=0.42346 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=0.42415 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.42451 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.4439 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.4486 μM | SANGER | |||
| RT4 | Growth Inhibition Assay | IC50=0.45111 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=0.4527 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.46195 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=0.46519 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=0.47643 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.47821 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.48933 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.49511 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.49904 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.50365 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.51808 μM | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | IC50=0.52135 μM | SANGER | |||
| K052 | Growth Inhibition Assay | IC50=0.5214 μM | SANGER | |||
| EHEB | Growth Inhibition Assay | IC50=0.52182 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=0.52351 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.52528 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.52781 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.54958 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=0.55735 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.56056 μM | SANGER | |||
| ECC12 | Growth Inhibition Assay | IC50=0.56558 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.57463 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.58344 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.58379 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=0.59615 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.61467 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=0.61715 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=0.62522 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.63069 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.63295 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=0.63352 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.6481 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.65672 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.6647 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=0.66779 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.68148 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=0.69738 μM | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | IC50=0.70887 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=0.71063 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.72405 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.72741 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=0.73349 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.73538 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.73653 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.73877 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.77278 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.77451 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.77501 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=0.78081 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.78733 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.79449 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.80529 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.80714 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=0.81407 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.81897 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.82441 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=0.84701 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.85732 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=0.85801 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.85846 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=0.86051 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=0.87933 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=0.89297 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.89548 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.92469 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.93292 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=0.93695 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=0.95014 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=0.95461 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.95543 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.96387 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.96564 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.9975 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.99775 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=1.00494 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=1.0097 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=1.01252 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=1.01375 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=1.01732 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=1.02244 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=1.02616 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=1.03109 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=1.03959 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=1.08073 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=1.09286 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=1.09633 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=1.11438 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=1.14128 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=1.15368 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=1.1616 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=1.1649 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=1.16936 μM | SANGER | |||
| ARH-77 | Growth Inhibition Assay | IC50=1.22924 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=1.2349 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=1.23536 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=1.24346 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=1.25636 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=1.28269 μM | SANGER | |||
| NCI-H1734 | Growth Inhibition Assay | IC50=1.28913 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=1.29542 μM | SANGER | |||
| NCI-H838 | Growth Inhibition Assay | IC50=1.30615 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=1.33755 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=1.37993 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=1.39595 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=1.40914 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=1.43114 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=1.48687 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=1.52054 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=1.52311 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=1.53906 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=1.54243 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=1.55741 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=1.5816 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=1.58663 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=1.6294 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=1.63902 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=1.64473 μM | SANGER | |||
| Calu-1 | Growth Inhibition Assay | IC50=1.65386 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=1.66611 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=1.66781 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=1.68311 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=1.69854 μM | SANGER | |||
| RL95-2 | Growth Inhibition Assay | IC50=1.71463 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=1.72719 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=1.73427 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=1.76358 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=1.78995 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=1.79721 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=1.81282 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=1.81606 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.83767 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=1.85851 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=1.86266 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=1.89074 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=1.90271 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=1.90675 μM | SANGER | |||
| SNG-M | Growth Inhibition Assay | IC50=1.95858 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=1.97516 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=1.99179 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=2.0109 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=2.02273 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=2.04207 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=2.07851 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=2.08433 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=2.08855 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=2.09711 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=2.13817 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=2.16373 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=2.18576 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=2.19019 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=2.23951 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=2.33184 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=2.33235 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=2.41048 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=2.41271 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=2.42029 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=2.44029 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=2.45382 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=2.49737 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=2.56826 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=2.5821 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=2.58487 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=2.58605 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=2.58872 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=2.64807 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=2.68792 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=2.70747 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=2.71845 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=2.73366 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=2.75632 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=2.78513 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=2.78969 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=2.88535 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=2.90191 μM | SANGER | |||
| C-4-II | Growth Inhibition Assay | IC50=2.91353 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=2.96769 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=3.08184 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=3.08882 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=3.10995 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=3.13518 μM | SANGER | |||
| BOKU | Growth Inhibition Assay | IC50=3.14256 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=3.17362 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=3.18483 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=3.20173 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=3.22039 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=3.25976 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=3.2658 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=3.33224 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=3.36186 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=3.36287 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=3.38051 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=3.45732 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=3.48263 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=3.49333 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=3.49692 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=3.56433 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=3.61552 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=3.65921 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=3.6626 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=3.66437 μM | SANGER | |||
| EW-7 | Growth Inhibition Assay | IC50=3.67693 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=3.71837 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=3.73028 μM | SANGER | |||
| NCI-H1618 | Growth Inhibition Assay | IC50=3.81875 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=3.81916 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=3.83126 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=3.87009 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=3.9067 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=3.92849 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=4.07974 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=4.08306 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=4.11255 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=4.16997 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=4.28299 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=4.3378 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=4.48149 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=4.48432 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=4.51793 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=4.53172 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=4.59293 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=4.66771 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=4.70048 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=4.72101 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=4.77043 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=4.83281 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=4.90487 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=4.97708 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=5.07497 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=5.09959 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=5.14645 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=5.16925 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=5.27582 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=5.35007 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=5.35107 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=5.3943 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=5.39631 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=5.43364 μM | SANGER | |||
| SNU-475 | Growth Inhibition Assay | IC50=5.47171 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=5.48494 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=5.62853 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=5.63534 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=5.75929 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=5.76846 μM | SANGER | |||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=5.87536 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=5.9244 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=5.96861 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=6.48267 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=6.55182 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=6.65774 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=6.82011 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=6.91688 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=6.97826 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=7.15406 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=7.27046 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=7.28605 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=7.29571 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=7.37235 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=7.38205 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=7.40798 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=7.44908 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=7.45762 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=7.77029 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=7.79762 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=8.00694 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=8.07508 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=8.10744 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=8.12833 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=8.13175 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=8.193 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=8.2872 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=8.35943 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=8.36304 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=8.47133 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=8.63246 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=8.75455 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=8.76832 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=8.7894 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=8.81062 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=8.83796 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=8.85081 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=8.87892 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=8.89926 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=8.97732 μM | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | IC50=8.98606 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=9.0346 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=9.06313 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=9.44731 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=9.44848 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=9.49703 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=9.6257 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=9.68766 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=9.7899 μM | SANGER | |||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=9.79495 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=9.84933 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=10.072 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=10.1657 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=10.2114 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=10.3179 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=10.328 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=10.5693 μM | SANGER | |||
| SK-CO-1 | Growth Inhibition Assay | IC50=10.777 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=10.9888 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=11.1131 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=11.1576 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=11.4336 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=11.7195 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=11.8126 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=11.9091 μM | SANGER | |||
| IPC-298 | Growth Inhibition Assay | IC50=11.9383 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=12.0218 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=12.1141 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=12.2299 μM | SANGER | |||
| DMS-53 | Growth Inhibition Assay | IC50=12.2649 μM | SANGER | |||
| NCI-H322M | Growth Inhibition Assay | IC50=12.3357 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=12.4904 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=12.614 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=12.6444 μM | SANGER | |||
| EFE-184 | Growth Inhibition Assay | IC50=12.7106 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=12.9247 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=13.339 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=13.3749 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=13.7163 μM | SANGER | |||
| HCC1143 | Growth Inhibition Assay | IC50=13.7437 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=13.8982 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=13.9489 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=14.1112 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=14.4085 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=14.4851 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=14.6215 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=14.7068 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=14.7556 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=14.773 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=14.786 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=14.8862 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=14.8997 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=14.9766 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=15.1599 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=15.2317 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=15.5305 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=15.8033 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=15.9979 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=16.0562 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=16.0667 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=16.2825 μM | SANGER | |||
| TT | Growth Inhibition Assay | IC50=16.5888 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=16.8273 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=16.9717 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=17.1479 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=17.3188 μM | SANGER | |||
| EB-3 | Growth Inhibition Assay | IC50=17.576 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=17.7035 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=17.7526 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=17.8085 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=17.9546 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=18.2781 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=18.3229 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=18.6947 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=18.7746 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=18.8255 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=19.3894 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=19.4148 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=19.5899 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=19.6737 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=20.0212 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=20.1043 μM | SANGER | |||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=20.3906 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=20.4525 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=20.6769 μM | SANGER | |||
| DMS-79 | Growth Inhibition Assay | IC50=20.849 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=20.9556 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=21.4462 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=21.4939 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=21.6122 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=21.6142 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=21.6864 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=21.8051 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=21.8982 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=21.9819 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=22.5363 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=22.554 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=22.7111 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=22.7517 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=22.8606 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=23.0344 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=23.3968 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=24.0641 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=24.0668 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=24.9282 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=25.2877 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=25.3316 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=25.3498 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=25.6833 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=25.6853 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=25.7879 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=25.9656 μM | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | IC50=25.9911 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=26.1708 μM | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | IC50=26.2738 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=26.4002 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=26.5675 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=27.2698 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=27.3598 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=27.4225 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=27.5053 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=27.6622 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=27.6878 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=27.7783 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=28.2166 μM | SANGER | |||
| RL | Growth Inhibition Assay | IC50=28.5911 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=28.6535 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=29.0565 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=29.0586 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=29.1831 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=29.3001 μM | SANGER | |||
| COLO-205 | Growth Inhibition Assay | IC50=29.3944 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=29.6877 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=29.8582 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=30.1919 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=31.2659 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=31.3561 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=31.5115 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=32.4179 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=32.4182 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=32.6501 μM | SANGER | |||
| CAL-148 | Growth Inhibition Assay | IC50=32.6665 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=32.9338 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=33.1705 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=33.4601 μM | SANGER | |||
| LP-1 | Growth Inhibition Assay | IC50=34.09 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=34.5069 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=35.1426 μM | SANGER | |||
| SNU-C1 | Growth Inhibition Assay | IC50=35.171 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=35.4076 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=35.5598 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=35.6691 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=36.0294 μM | SANGER | |||
| COR-L279 | Growth Inhibition Assay | IC50=36.1981 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=36.8516 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=36.8571 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=36.8675 μM | SANGER | |||
| DV-90 | Growth Inhibition Assay | IC50=36.9067 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=36.9318 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=36.9654 μM | SANGER | |||
| HCC1599 | Growth Inhibition Assay | IC50=37.1618 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=37.2503 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=37.2868 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=37.2891 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=37.3233 μM | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | IC50=37.3624 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=37.567 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=38.3492 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=38.4489 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=38.7344 μM | SANGER | |||
| ECC4 | Growth Inhibition Assay | IC50=39.0814 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=39.1235 μM | SANGER | |||
| NCI-H2227 | Growth Inhibition Assay | IC50=39.3949 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=39.8398 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=40.096 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=40.1828 μM | SANGER | |||
| MDA-MB-468 | Growth Inhibition Assay | IC50=40.5346 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=41.2075 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=41.2179 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=41.2732 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=41.2885 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=42.1886 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=42.2854 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=42.8974 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=43.0388 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=43.3189 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=43.464 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=43.762 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=43.9099 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=43.9281 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=44.4347 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=44.4474 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=44.708 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=44.7937 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=45.9581 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=46.1723 μM | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | IC50=46.2155 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=46.7185 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=46.9373 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=47.2066 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=47.4216 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=47.888 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=48.076 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=48.1704 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=48.3031 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=48.3815 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=48.7067 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=49.5543 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=49.8085 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=49.8087 μM | SANGER | |||
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Chemische Informationen, Lagerung & Stabilität
| Molekulargewicht | 532.56 | Formel | C29H27F3N6O |
Lagerung (Ab dem Eingangsdatum) | |
|---|---|---|---|---|---|
| CAS-Nr. | 943319-70-8 | SDF herunterladen | Lagerung von Stammlösungen |
|
|
| Synonyme | AP24534 | Smiles | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 | ||
Löslichkeit
|
In vitro |
DMSO
: 73 mg/mL
(137.07 mM)
Water : Insoluble Ethanol : Insoluble |
Molaritätsrechner
Verdünnungsrechner
Molekulargewichtsrechner
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In vivo |
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In-vivo-Formulierungsrechner (Klare Lösung)
Schritt 1: Geben Sie die untenstehenden Informationen ein (Empfohlen: Ein zusätzliches Tier zur Berücksichtigung von Verlusten während des Experiments)
mg/kg
g
μL
Schritt 2: Geben Sie die In-vivo-Formulierung ein (Dies ist nur der Rechner, keine Formulierung. Bitte kontaktieren Sie uns zuerst, wenn es im Abschnitt "Löslichkeit" keine In-vivo-Formulierung gibt.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Berechnungsergebnisse:
Arbeitskonzentration: mg/ml;
Methode zur Herstellung der DMSO-Stammlösung: mg Wirkstoff vorgelöst in μL DMSO ( Konzentration der Stammlösung mg/mL, Bitte kontaktieren Sie uns zuerst, wenn die Konzentration die DMSO-Löslichkeit der Wirkstoffcharge überschreitet. )
Methode zur Herstellung der In-vivo-Formulierung: Nehmen Sie μL DMSO Stammlösung, dann hinzufügenμL PEG300, mischen und klären, dann hinzufügenμL Tween 80, mischen und klären, dann hinzufügen μL ddH2O, mischen und klären.
Methode zur Herstellung der In-vivo-Formulierung: Nehmen Sie μL DMSO Stammlösung, dann hinzufügen μL Maisöl, mischen und klären.
Hinweis: 1. Bitte stellen Sie sicher, dass die Flüssigkeit klar ist, bevor Sie das nächste Lösungsmittel hinzufügen.
2. Achten Sie darauf, das/die Lösungsmittel der Reihe nach hinzuzufügen. Sie müssen sicherstellen, dass die bei der vorherigen Zugabe erhaltene Lösung eine klare Lösung ist, bevor Sie mit der Zugabe des nächsten Lösungsmittels fortfahren. Physikalische Methoden wie Vortex, Ultraschall oder ein heißes Wasserbad können zur Unterstützung des Lösens verwendet werden.
Wirkmechanismus
| Targets/IC50/Ki |
Abl
(Cell-free assay) 0.37 nM
PDGFRα
(Cell-free assay) 1.1 nM
VEGFR2
(Cell-free assay) 1.5 nM
FGFR1
(Cell-free assay) 2.2 nM
c-Src
(Cell-free assay) 5.4 nM
c-Kit
(Cell-free assay) 12.5 nM
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|---|---|
| In vitro |
AP24534 hemmt potent natives Abl, AblT315I und andere klinisch wichtige Abl-Kinase-Domänenmutanten mit einer IC50 von 0,30 nM–2 nM. Diese Verbindung hemmt weder Mitglieder der Aurora-Kinasefamilie noch den Insulinrezeptor oder CDK2/Cyclin E. Sie hemmt die Proliferation von Ba/F3-Zellen, die Bcr-Abl exprimieren, mit einer IC50 von 0,5 nM, sowie Ba/F3-Zellen, die eine Reihe von Bcr-Abl-Mutanten exprimieren, mit einer IC50 von 0,5 nM–36 nM. Die Hemmung der Proliferation durch diese Chemikalie korreliert mit der Induktion von Apoptose. In Leukämiezelllinien, die aktivierte Formen von FLT3-, KIT-, FGFR1- und PDGFRα-Rezeptoren enthalten, hemmt es potent die Rezeptorphosphorylierung und die Zellproliferation mit einer IC50 von 0,3 nM bis 20 nM. In MV4-11 (FLT3-ITD(+/+))-, aber nicht in RS4;11 (FLT3-ITD(–/–))-AML-Zellen hemmt dieser Inhibitor die FLT3-Signalübertragung und induziert Apoptose bei weniger als 10 nM. Er hemmt die Lebensfähigkeit primärer Leukämie-Blasten von einem FLT3-ITD-positiven AML-Patienten mit einer IC50 von 4 nM, aber nicht die von Patienten mit AML, die natives FLT3 exprimieren. In Ba/F3-Zellen, die zur Expression von aktiviertem FGFR1-4 entwickelt wurden, hemmt dieses Mittel potent die FGFR-vermittelte Signalübertragung und Lebensfähigkeit mit einer IC50 von weniger als 40 nM. In Zelllinien, die verschiedene Tumortypen (Endometrium, Blase, Magen, Brust, Lunge und Kolon) repräsentieren und FGFRs enthalten, die durch eine Vielzahl von Mechanismen dysreguliert sind, hemmt es die FGFR-vermittelte Signalübertragung mit einer IC50 von weniger als 40 nM und hemmt das Zellwachstum mit einer IC50 von 7 nM–181 nM.
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| Kinase-Assay |
Peptidsubstrat-Phosphorylierungsassays mit GST-Abl-Kinase-Domänen
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Die Wirkung von AP24534 (0-320 nM) auf die GST-Abl-Kinaseaktivität wird unter Verwendung eines synthetischen Peptidsubstrats (Abltide: EAIYAAPFAKKK) bewertet. Die Assays werden bei 30 °C für 15 Minuten in einem 25 μL Reaktionsgemisch durchgeführt: 8 mM MOPS (pH 7), 0,2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-Glycerophosphat, 1 mM EGTA, 0,002% Brij-35, 0,4 mM DTT, 0,2 mg/mL BSA, 0,4 mM Natriumorthovanadat, 10 nM WT oder mutierte GST-Abl-Kinase und 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Die Reaktionen werden durch Übertragung eines Teils des Reaktionsgemisches auf einen p81 Phosphocellulosefilter und Eintauchen in 0,75%ige Phosphorsäure beendet. Die Filter werden 3-mal in 0,75%iger Phosphorsäure gewaschen, in Aceton gespült und an der Luft getrocknet; der Phosphateinbau wird durch Szintillationszählung bestimmt. Alle Ergebnisse werden für die Hintergrundbindung an die Filter korrigiert, die durch Weglassen des Peptidsubstrats aus der Kinase-Reaktion bestimmt wird. Zeitverlaufsexperimente zur Bestimmung des linearen Bereichs der enzymatischen Aktivität gehen den Kinase-Assays voraus.
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| In vivo |
In einem Maus-Xenograft-Modell von Ba/F3-Zellen, die natives Bcr-Abl exprimieren, verlängert diese Verbindung (2,5 mg/kg und 5 mg/kg) die mittlere Überlebenszeit der Mäuse. Im Xenograft-Modell von Ba/F3 Bcr-AblT315I unterdrückt diese Verbindung (10 mg/kg–50 mg/kg) signifikant das Tumorwachstum. Sie (30 mg/kg) verringert die phosphorylierten Bcr-Abl- und phosphorylierten CrkL-Spiegel in den Tumoren.
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Literatur |
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Anwendungen
| Methoden | Biomarker | Bilder | PMID |
|---|---|---|---|
| Western blot | pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 pFGFR1(pY20) / FGFR1 cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2 p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1 RAD51 p-MEK / MEK / p-ERK / ERK c-Jun / p-JNK(T183/Y185) / JNK p-p38 MAPK / p38 MAPK p-JAK2 / JAK2 / p-STAT3 / STAT3 PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR p-PDGFRα / PDGFRα PARP / Caspase-3 / Active Caspase-3 AIF / Cyto C Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim β-catenin β-catenin ABL |
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22781593 |
| Growth inhibition assay | Cell viability |
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30174789 |
Klinische Studieninformationen
(Daten von https://clinicaltrials.gov, aktualisiert am 2024-05-22)
| NCT-Nummer | Rekrutierung | Erkrankungen | Sponsor/Kooperationspartner | Startdatum | Phasen |
|---|---|---|---|---|---|
| NCT05306301 | Recruiting | Chemotherapy|Leukemia Acute Lymphoblastic |
Gruppo Italiano Malattie EMatologiche dell''Adulto |
October 5 2022 | Phase 2 |
| NCT05268003 | Recruiting | Acute Lymphoblastic Leukemia|Leukemia |
M.D. Anderson Cancer Center |
June 7 2022 | Phase 2 |
Technischer Support
Tel: +1-832-582-8158 Ext:3
Wenn Sie weitere Fragen haben, hinterlassen Sie bitte eine Nachricht.
Häufig gestellte Fragen
Frage 1:
Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?
Antwort:
Our 10mM solution in DMSO is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for this compound is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.
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