Home DNA Damage/DNA Repair Antineoplastic and Immunosuppressive Antibiotics Inhibitor Doxorubicin (Adriamycin) Hydrochloride

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Doxorubicin (Adriamycin) Hydrochloride DNA Topoisomerase II Inhibitor

Kat.-Nr.S1208

Doxorubicin (DOX) HCl ist ein Antibiotikum, das die menschliche DNA Topoisomerase II mit einer IC50 von 2,67 μM hemmt. Doxorubicin reduziert die basale Phosphorylierung von AMPK. Doxorubicin wird in der begleitenden Behandlung von HIV-infizierten Patienten eingesetzt, birgt jedoch ein hohes Risiko einer HBV-Reaktivierung.Dieses Produkt kann beim Auflösen in PBS-Lösung ausfallen. Es wird empfohlen, die Stammlösung in reinem Wasser herzustellen und mit reinem Wasser oder Salzlösung zu verdünnen, um die Arbeitslösung zu erhalten.Doxorubicin (Adriamycin) HCl kann zur Induktion von Tiermodellen für Nierenerkrankungen verwendet werden.
Doxorubicin (Adriamycin) Hydrochloride Antineoplastic and Immunosuppressive Antibiotics Inhibitor Chemical Structure

Chemische Struktur

Molekulargewicht: 579.98

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Charge: Reinheit: 99.82%
99.82

Zellkultur, Behandlung & Arbeitskonzentration

Zelllinien Assay-Typ Konzentration Inkubationszeit Formulierung Aktivitätsbeschreibung PMID
SGC7901 Growth Inhibition Assay 10 μM 72 h DMSO GI50=0.55 μM 24686011
HLF Growth Inhibition Assay 10 μM 72 h DMSO GI50=0.33 μM 24686011
16HBE Growth Inhibition Assay 10 μM 72 h DMSO GI50=0.18 μM 24650643
BALB/3T3 Growth Inhibition Assay IC50=0.5 μM 24631190
26-L5 Function Assay 6 h Antiinvasive activity 24592993
CEM/ADR5000 Cytotoxic Assay DMSO Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells expressing p-glycoprotein with IC50 of 23.27 μM 24561670
CCRF-CEM Cytotoxic Assay DMSO IC50=0.009 μM 24561670
V79 Cytotoxic Assay 1.10 μM 72 h DMSO IC50=0.24 μM 24530030
MX1 Cytotoxic Assay 1.10 μM 72 h DMSO IC50=0.5 μM 24530030
L929 Cytotoxic Assay 1.10 μM 72 h DMSO IC50=0.16 μM 24530030
ME180 Cytotoxic Assay 48 h IC50=0.39 μM 24487188
MGC803 Cytotoxic Assay 72 h IC50=0.17 μM 24370114
CHP100 Cytotoxic Assay 72 h IC50=0.79 μM 24251417
Bel7402 Growth Inhibition Assay 96 h DMSO IC50=0.5782 μM 24211639
SGC7901 Cytotoxic Assay IC50=0.011 μM 24195466
MKN28 Growth Inhibition Assay 48 h GI50=0.24 μM 24184076
Caco2 Growth Inhibition Assay 48 h GI50=0.32 μM 24184076
MDA-MB-468 Growth Inhibition Assay 10 μM 72 h GI50=0.085 μM 24163729
Caco2 Cytotoxic Assay 40 μM 24 h Cytotoxicity 24099994
U2OS Growth Inhibition Assay 72 h IC50=0.3 μM 24095089
OVCAR8 Growth Inhibition Assay 20 μM 72 h Antiproliferative activity 24095089
LNcaP Function Assay 3 μM 24 h Up-regulation of p53 expression 24095089
LNcaP Function Assay 3 μM 24 h Increase of cleaved caspase-9 level 24095089
Caov3 Growth Inhibition Assay 72 h IC50=0.1 μM 24095089
AS49-RAW Cytotoxic Assay 100 μM 48 h IC50=32.78 μM 24077528
MDA-MB-435 Cytotoxic Assay 100 μM 48 h IC50=0.15 μM 24028446
HUVEC Function Assay 5 μM 2 h Cellular uptake 24028446
MRC5 Growth Inhibition Assay 72 h IC50=0.1 μM 24021462
HepG2 Function Assay 40 μg/mL 48 h DMSO Inhibition of TRK with IC50 of 0.0025 μM 24013411
HUVEC Cytotoxic Assay 48 h IC50=0.0807 μM 24012378
KB/HeLa Cytotoxic Assay 45 h EC50=0.25 μM 23988351
MDA-MB-231 Function Assay 5 μM 24 h Antioxidant activity assessed as intramitochondrial ROS level 23973213
MDA-MB-231 Function Assay 5 μM 24 h Antioxidant activity assessed as intracellular malonyldialdehyde level 23973213
MDA-MB-231 Function Assay 5 μM 24 h Cellular uptake 23973213
MCF7 Function Assay 5 μM 24 h Cellular uptake 23973213
MCF7 Function Assay 5 μM 24 h Antioxidant activity assessed as intracellular malonyldialdehyde level 23973213
MCF7 Function Assay 5 μM 24 h Cellular uptake 23973213
MCF7 Function Assay 5 μM 24 h Antioxidant activity assessed as intramitochondrial ROS level 23973213
H9c2 Function Assay 5 μM 24 h Cellular uptake 23973213
H9c2 Function Assay 5 μM 24 h Antioxidant activity assessed as intracellular ROS level 23973213
H9c2 Function Assay 5 μM 24 h Antioxidant activity assessed as intracellular malonyldialdehyde level 23973213
H9c2 Function Assay 5 μM 24 h Antioxidant activity assessed as intramitochondrial ROS level 23973213
HaCaT Growth Inhibition Assay 25 μg/mL 48 h TGI50=0.4 μM 23876338
UO31 Cytotoxic Assay 100 μM 48 h GI50=0.49 μM 23871905
UACC257 Cytotoxic Assay 100 μM 48 h GI50=0.14 μM 23871905
U251 Cytotoxic Assay 100 μM 48 h GI50=0.04 μM 23871905
TK10 Cytotoxic Assay 100 μM 48 h GI50=0.18 μM 23871905
SR Cytotoxic Assay 100 μM 48 h GI50=0.03 μM 23871905
SNB75 Cytotoxic Assay 100 μM 48 h GI50=0.07 μM 23871905
SNB19 Cytotoxic Assay 100 μM 48 h GI50=0.04 μM 23871905
SN12C Cytotoxic Assay 100 μM 48 h GI50=0.07 μM 23871905
SK-MEL-28 Cytotoxic Assay 100 μM 48 h GI50=0.21 μM 23871905
SF539 Cytotoxic Assay 100 μM 48 h GI50=0.12 μM 23871905
RXF393 Cytotoxic Assay 100 μM 48 h GI50=0.1 μM 23871905
PRMI8226 Cytotoxic Assay 100 μM 48 h GI50=0.08 μM 23871905
OVCAR-8 Cytotoxic Assay 100 μM 48 h GI50=0.1 μM 23871905
OVCAR5 Cytotoxic Assay 100 μM 48 h GI50=0.41 μM 23871905
OVCAR4 Cytotoxic Assay 100 μM 48 h GI50=0.37 μM 23871905
NCI-H522 Cytotoxic Assay 100 μM 48 h GI50=0.03 μM 23871905
NCI-H322M Cytotoxic Assay 100 μM 48 h GI50=0.54 μM 23871905
NCI-H226 Cytotoxic Assay 100 μM 48 h GI50=0.05 μM 23871905
MALME-3M Cytotoxic Assay 100 μM 48 h GI50=0.12 μM 23871905
M14 Cytotoxic Assay 100 μM 48 h GI50=0.18 μM 23871905
LOXIMVI Cytotoxic Assay 100 μM 48 h GI50=0.07 μM 23871905
KM12 Cytotoxic Assay 100 μM 48 h GI50=0.27 μM 23871905
IGROVI Cytotoxic Assay 100 μM 48 h GI50=0.17 μM 23871905
HOP92 Cytotoxic Assay 100 μM 48 h GI50=0.1 μM 23871905
HCC2998 Cytotoxic Assay 100 μM 48 h GI50=0.26 μM 23871905
EKVX Cytotoxic Assay 100 μM 48 h GI50=0.41 μM 23871905
Caki1 Cytotoxic Assay 100 μM 48 h GI50=0.95 μM 23871905
ACHN Cytotoxic Assay 100 μM 48 h GI50=0.08 μM 23871905
786-0 Cytotoxic Assay 100 μM 48 h GI50=0.13 μM 23871905
HOP62 Growth Inhibition Assay 100 μM 48 h GI50=0.14 μM 23849207
Gurav Growth Inhibition Assay 100 μM 48 h GI50=0.17 μM 23849207
DWD Growth Inhibition Assay 100 μM 48 h GI50=0.1 μM 23849207
COLO205 Growth Inhibition Assay 100 μM 48 h GI50=0.14 μM 23849207
LS180 Cytotoxic Assay 72 h DMSO IC50=0.04 μM 23827179
786 Cytotoxic Assay 48 h DMSO IC50=0.33 μM 23810282
HGF Cytotoxic Assay 25 mM 24 h IC50=0.5 μM 23802716
C643 Cytotoxic Assay 25 mM 24 h IC50=0.07 μM 23802716
B16F10 Cytotoxic Assay 48 h DMSO IC50=0.072 μM 23777898
JURKAT-TALL Cytotoxic Assay 48 h IC50=0.0096 μM 23673218
U266 Cytotoxic Assay 72 h IC50=0.67 μM 23600925
SW872 Cytotoxic Assay 72 h IC50=0.14 μM 23600925
SK-UT-1 Cytotoxic Assay 72 h IC50=0.076 μM 23600925
SK-ES-1 Cytotoxic Assay 72 h IC50=0.042 μM 23600925
SK-BR-3 Cytotoxic Assay 72 h IC50=0.09 μM 23600925
NCI-H929 Cytotoxic Assay 72 h IC50=0.065 μM 23600925
MNNG-HOS Cytotoxic Assay 72 h IC50=0.59 μM 23600925
MDA-MB-436 Cytotoxic Assay 72 h IC50=0.1 μM 23600925
A673 Apoptosis Assay 24 h DMSO Induction of apoptosis assessed as caspase-3 activation with EC50 of 0.39 μM 23600925
A673 Cytotoxic Assay 72 h Cytotoxicity against human A673 cells after 72 hrs by resazurin/resorufin-based fluorescence assay with IC50 of 0.17 μM 23600925
MA9.3 Cytotoxic Assay 100 μM 48 h IC50=0.086 μM 23578690
SK-MEL Cytotoxic Assay 48 h DMSO IC50=1.5 μM 23547843
HeLa Cytotoxic Assay 1 μM 72 h IC50=0.01 μM 23470139
POS1 Growth Inhibition Assay 72 h IC50=0.043 μM 23360521
OSRGA Growth Inhibition Assay 72 h IC50=0.093 μM 23360521
L929 Growth Inhibition Assay 72 h IC50=0.161 μM 23360521
AT6-1 Growth Inhibition Assay 72 h IC50=2 μM 23360521
WHCO1 Cytotoxic Assay 48 h DMSO IC50=0.5 μM 23353747
MOLT4 Cytotoxic Assay 48 h DMSO IC50=0.02 μM 23218718
MGC803 Growth Inhibition Assay 20 μM 72 h DMSO IC50=0.7 μM 23124210
Bcap37 Growth Inhibition Assay 20 μM 72 h DMSO IC50=1.28 μM 23124210
HL60/Vinc Cytotoxic Assay 100 μg/mL 72 h DMSO Cytotoxicity against human HL60/Vinc cells with IC50 of 0.91 μM 23079523
BALB/3T3 Cytotoxic Assay 100 μg/mL 72 h DMSO IC50=1.91 μM 23079523
MG63 Cytotoxic Assay IC50=2.7 μM 23043498
HL60/A Cytotoxic Assay 18 h IC50=6.7 μM 22985027
A549 Cytotoxic Assay IC50=0.001 μM 22951040
MESSA/DX5 Growth Inhibition Assay 100 μg/mL 72 h DMSO IC50=0.25 μM 22944121
SKLU1 Cytotoxic Assay 48 h DMSO IC50=0.0067 μM 22858298
HCT15 Cytotoxic Assay 48 h DMSO IC50=0.005 μM 22858298
U2OS Cytotoxic Assay 4 μM 72 h DMSO IC50=3.4 μM 22749279
B16 48 h IC50=0.03 μM 22668451
MKN45 Cytotoxic Assay 48 h DMSO IC50=0.168 μM 22647723
HMEC1 Cytotoxic Assay 250 μg/mL 72 h IC50=0.06 μM 22616554
BMDM Cytotoxic Assay 250 μg/mL 72 h IC50=4.6 μM 22616554
J774A.1 Cytotoxic Assay 72 h DMSO IC50=0.02 μM 22608675
WI38 Growth Inhibition Assay 100 μM 72 h DMSO IC50=0.04 μM 22555152
SW620 Growth Inhibition Assay 100 μM 72 h DMSO IC50=0.04 μM 22555152
NCI/ADR Growth Inhibition Assay 25 μg/mL 48 h IC50=13.5 μM 22537680
786-0 Growth Inhibition Assay 25 μg/mL 48 h IC50=2.1 μM 22537680
SMMC7721 Cytotoxic Assay 500 μM 48 h DMSO IC50=0.37 μM 22537362
KB/VCR Cytotoxic Assay 500 μM 48 h DMSO IC50=0.45 μM 22537362
U87MG Growth Inhibition Assay 2 μM 48 h IC50=0.79 μM 22515366
NCI-H290 Growth Inhibition Assay 2 μM 48 h IC50=0.32 μM 22515366
LLC Growth Inhibition Assay 48 h IC50=0.207 μM 22515366
XF498 Cytotoxic Assay 48 h IC50=0.015 μM 22483395
SK-MEL-2 Cytotoxic Assay 48 h IC50=0.002 μM 22483395
K562/A02 Growth Inhibition Assay 72 h DMSO Antiproliferative activity against multidrug-resistant human K562/A02 cells overexpressing p-glycoprotein with IC50 of 46.69 μM 22450134
HuH7 Growth Inhibition Assay 25 ng/mL 72 h DMSO Antiproliferative activity assessed as inhibition of BrdU incorporation 22409771
HuH7 Function Assay 25 ng/mL 72 h DMSO Induction of senescence assessed as increase in senescence associated beta-galactosidase activity 22409771
SK-N-SH Cytotoxic Assay 48 h IC50=0.97 μM 22386528
SiHa Growth Inhibition Assay GI50=0.14 μM 22361684
B16 Cytotoxic Assay 72 h DMSO IC50=0.1 μM 22330634
SKOV3 Function Assay 5 μM 1 h DMSO Cellular uptake in doxorubicin-resistant human SKOV3 cells 22276998
SKOV3 Function Assay 5 μM 1 h DMSO Drug uptake in doxorubicin-resistant human SKOV3 cell nucleu 22276998
LNcaP Apoptosis Assay 20 μg/mL 24 h water Induction of apoptosis assessed as increase in caspase 3/7 activation 22264758
PC3M Cytotoxic Assay 72 h DMSO IC50=0.24 μM 22264149
QGY7701 Cytotoxic Assay 24 h DMSO IC50=8.65 μM 22182926
A375-C5 Growth Inhibition Assay 48 h DMSO GI50=0.0915 μM 22177409
RAW264.7 Cytotoxic Assay 10 μM 24 h DMSO Cytotoxicity assessed as cell viability 22129061
SKOV3 Growth Inhibition Assay 50 μM 72 h DMSO Antiproliferative activity against human SKOV3 cells overexpressing c-Src 22119472
BGC823 Cytotoxic Assay 96 h DMSO IC50=0.98 μM 22070654
HCT8 Cytotoxic Assay 5 μg/mL 72 h DMSO IC50=0.02 μM 22000949
MCF7 Function Assay 50 μg/mL 48 h DMSO Reduction in AP-2 gamma mRNA expression 22000946
MCF7 Function Assay 50 μg/mL 48 h DMSO Reduction in CYP19 mRNA expression 22000946
MCF7 Function Assay 50 μg/mL 48 h DMSO Reduction in VEGF mRNA expression 22000946
Neuro2a Cytotoxic Assay 72 h IC50=1.2 μM 21996519
PC3 Growth Inhibition Assay 48 h GI50=0.09 μM 21875046
AGS Growth Inhibition Assay 48 h GI50=0.01 μM 21875046
BT20 Growth Inhibition Assay 10 μM 72 h Antiproliferative activity 21852023
K562/A02 Cytotoxic Assay 48 h DMSO IC50=17.84 μM 21843940
Ca9-22 Cytotoxic Assay 72 h DMSO IC50=0.26 μM 21800859
SH-SY5Y Cytotoxic Assay 48 h IC50=0.5 μM 21797280
LAMA-84 Cytotoxic Assay 48 h IC50=0.74 μM 21797280
A2780/ADR Cytotoxic Assay IC50=0.194 μM 21774499
A2780 Cytotoxic Assay IC50=0.0012 μM 21774499
NCI-H187 Cytotoxic Assay 72 h IC50=0.03 μM 21741833
KATO Cytotoxic Assay 72 h IC50=0.33 μM 21741833
ChaGo Cytotoxic Assay 72 h IC50=0.83 μM 21741833
BT474 Cytotoxic Assay 72 h IC50=0.07 μM 21741833
HFF Cytotoxic Assay 72 h CC50=0.03 μM 21741131
Gurav Cytotoxic Assay 100 μM 48 h DMSO GI50<0.1 μM 21737288
ZR-75B Cytotoxic Assay 72 h IC50=2.02 μM 21721528
ZR-75B Cytotoxic Assay 72 h IC50=0.04 μM 21721528
SW620 Cytotoxic Assay 72 h IC50=0.01 μM 21721528
NIH3T3 Cytotoxic Assay 72 h IC50=0.05 μM 21721528
NCI/ADR-RES Cytotoxic Assay 72 h IC50=9.3 μM 21721528
LLC-PK1 Cytotoxic Assay 72 h IC50=0.2 μM 21721528
KBV1 Cytotoxic Assay 72 h IC50=4.7 μM 21721528
KB3-1 Cytotoxic Assay 72 h IC50=0.02 μM 21721528
HEK293 Cytotoxic Assay 72 h IC50=0.42 μM 21721528
HEK293 Cytotoxic Assay 72 h IC50=0.01 μM 21721528
Ew36 Cytotoxic Assay 72 h IC50=0.01 μM 21721528
MG63 Growth Inhibition Assay 72 h IC50=2.8 μM 21721519
PC3 Cytotoxic Assay 160 μg/mL 5 d DMSO GI50=0.021 μM 21711054
NCI-H23 Cytotoxic Assay 160 μg/mL 5 d DMSO GI50=0.005 μM 21711054
Hs578 Cytotoxic Assay 160 μg/mL 5 d DMSO GI50=0.006 μM 21711054
BT549 Cytotoxic Assay 160 μg/mL 5 d DMSO GI50=0.01 μM 21711054
HOP62 Cytotoxic Assay 24 h GI50=0.14 μM 21676506
SW480 Growth Inhibition Assay 48 h IC50=0.06 μM 21641694
S180 Growth Inhibition Assay 48 h IC50=29.2 μM 21620529
H22 Growth Inhibition Assay 48 h IC50=36.51 μM 21620529
P388D1 Growth Inhibition Assay IC50=0.338 μM 21570750
KATOIII Growth Inhibition Assay IC50=4.38 μM 21570750
SK-MEL-28 Growth Inhibition Assay 25 nM 24 h DMSO IC50=0.6 μM 21553829
SF295 Growth Inhibition Assay 25 nM 24 h DMSO IC50=4.4 μM 21553829
A375 Growth Inhibition Assay 72 h PBS IC50=0.13 μM 21496972
HCT8 Cytotoxic Assay 0.58 μg/mL 69 h DMSO IC50=0.02 μM 21381705
NCI-N87 Growth Inhibition Assay 96 h DMSO IC50=0.4198 μM 21296467
HUVEC Growth Inhibition Assay 96 h DMSO IC50=0.0303 μM 21296467
HepG2 Growth Inhibition Assay 96 h DMSO IC50=0.019 μM 21296467
CCRF Growth Inhibition Assay 96 h DMSO IC50=0.0375 μM 21296467
IMR90 Cytotoxic Assay 48 h DMSO IC50=0.59 μM 21215623
Molt4/C8 Cytotoxic Assay 72 h DMSO IC50=0.2 μM 21144624
CEM Cytotoxic Assay 72 h DMSO IC50=0.06 μM 21144624
MDA435 Cytotoxic Assay 10 μM 72 h DMSO IC50=0.0035 μM 21142180
MDA231 Cytotoxic Assay 10 μM 72 h DMSO IC50=4.7x10-5 μM 21142180
HL60R Cytotoxic Assay 10 μM 72 h DMSO IC50=0.99 μM 21142180
C33A Cytotoxic Assay 100 μg/mL 48 h IC50=0.82 μM 21071221
MKN45 Growth Inhibition Assay 72 h IC50=0.00019 μM 21067930
KB Growth Inhibition Assay 72 h IC50=0.00023 μM 21067930
H460 Growth Inhibition Assay 72 h IC50=0.00038 μM 21067930
KB8.5 Cytotoxic Assay 50 μM 72 h DMSO IC50=3.3 μM 21035234
BJ Cytotoxic Assay 48 h DMSO IC50=2.33 μM 20931970
ARPE19 Cytotoxic Assay 48 h DMSO IC50=0.76 μM 20931970
THP1 Cytotoxic Assay 72 h DMSO IC50=0.008 μM 20833057
SiHa Cytotoxic Assay 4 μM 24 h GI50=0.17 μM 20732817
DWD Cytotoxic Assay 4 μM 24 h GI50=0.1 μM 20732817
SKOV3 Cytotoxic Assay IC50=0.001 μM 20719504
Hep3B Cytotoxic Assay 11 d IC50=0.14 μM 20718475
COLO205 Cytotoxic Assay 48 h DMSO GI50=0.1 μM 20673627
HCT-15 Cytotoxic Assay IC50=0.038 μM 20594848
NUGC3 Cytotoxic Assay GI50=0.202 μM 20579876
CCRF-CEM Growth Inhibition Assay 48 h GI50=0.02 μM 20570145
HAEC Cytotoxic Assay 100 μM 24 h DMSO IC50=13 μM 20547797
PAXF1657L Cytotoxic Assay 10 μM 24 h IC50=0.052 μM 20545334
MEXF462NL Cytotoxic Assay 10 μM 24 h IC50=0.052 μM 20545334
MAXF401NL Cytotoxic Assay 10 μM 24 h IC50=0.052 μM 20545334
GXF251L Cytotoxic Assay 10 μM 24 h IC50=0.052 μM 20545334
CEM/ADR5000 Function Assay 1 μg/mL 6 h Increase in ROS generation 20527917
CEM/ADR5000 Apoptosis Assay 1 μg/mL 24 h Induction of apoptosis 20527917
PCO3 Cytotoxic Assay 250 μg/mL 48 h GI50=0.17 μM 20413188
OVCAR-3 Cytotoxic Assay 250 μg/mL 48 h GI50=0.07 μM 20413188
NCI/ADR Cytotoxic Assay 250 μg/mL 48 h GI50=5.99 μM 20413188
3T3 Cytotoxic Assay 10 μM 48 h IC50=3.7 μM 20405844
HBI10A Cytotoxic Assay CC50<0.3 μM 20363140
U937 Cytotoxic Assay 72 h IC50=0.00445 μM 20356655
NB-1 Cytotoxic Assay 72 h IC50=0.00515 μM 20356655
K562 Cytotoxic Assay 72 h IC50=0.00612 μM 20356655
HL60 Cytotoxic Assay 72 h IC50=0.00113 μM 20356655
GOTO Cytotoxic Assay 72 h IC50=0.00473 μM 20356655
SK-N-MC Cytotoxic Assay 72 h IC50=0.12 μM 20303768
U87MG Cytotoxic Assay 48 h IC50=0.018 μM 20210346
SKHEP1 Cytotoxic Assay 48 h IC50=0.01 μM 20210346
MIAPaCa2 Cytotoxic Assay 100 μM 72 h IC50=0.01 μM 20207049
SKHep Growth Inhibition Assay 48 h DMSO IC50=0.09 μM 20171108
MESSA/DX5 Function Assay 50 μM 2 h water Induction of DNA damage assessed as increase in comet-tail length 20151639
MESSA Function Assay 25 μM 2 h water Cellular uptake 20151639
MESSA Function Assay 50 μM 2 h water Induction of DNA damage assessed as increase in comet-tail length 20151639
MCF10A Cytotoxic Assay 40 μM 48 h DMSO IC50=0.18 μM 20064676
IMR32 Growth Inhibition Assay 48 h DMSO IC50=1.7 μM 19939522
MOLT3 Cytotoxic Assay IC50=0.04 μM 19824618
HuCCa1 Cytotoxic Assay 4 d IC50=0.64 μM 19824618
HCT15 Cytotoxic Assay IC50=0.037 μM 19819696
MDA-MB-453 Cytotoxic Assay 0.58 μg/mL 69 h DMSO IC50=0.12 μM 19788290
HL60/MX2 Cytotoxic Assay 48 h DMSO IC50=8.046 μM 19743858
2008/P Cytotoxic Assay 5 d DMSO IC50=0.063 μM 19725578
2008/MRP1 Cytotoxic Assay 5 d DMSO IC50=0.577 μM 19725578
Colon 26-L5 Cytotoxic Assay 72 h DMSO IC50=3.12 μM 19689125
B16-BL6 Cytotoxic Assay 72 h DMSO IC50=3.07 μM 19689125
KB Cytotoxic Assay 72 h DMSO IC50=0.001 μM 19655762
HCT116 Cytotoxic Assay 72 h DMSO IC50=0.006 μM 19655762
U251 Growth Inhibition Assay 72 h DMSO IC50=0.6 μM 19632833
OS-RC2 Growth Inhibition Assay 72 h DMSO IC50=5.4 μM 19632833
MOLT4 Growth Inhibition Assay 72 h DMSO IC50=0.002 μM 19632833
L78 Growth Inhibition Assay 72 h DMSO IC50=2.4 μM 19632833
IMR90 Growth Inhibition Assay 72 h DMSO IC50=1 μM 19632833
SK-N-SH Apoptosis Assay 5 μM Induction of apoptosis assessed as caspase 3 activity 19631549
SK-N-SH Apoptosis Assay 5 μM Induction of apoptosis at 0.5 to 5 uM 19631549
SNU1 Cytotoxic Assay IC50=4 μM 19585998
MDA-MB-231 Growth Inhibition Assay 200 μM 48 h DMSO Antitumor activity against human estrogen receptor deficient MDA-MB-231 cells with GI50 of 0.01086 μM 19428155
U251 Function Assay 1 μM 16 h DMSO Inhibition of HIF1 activation in human U251 cells stably transfected in pGL2-TK-HRE plasmid with EC50 of 0.12 μM 19405508
SKOV3 Growth Inhibition Assay GI50=0.021 μM 19394218
MESSA Growth Inhibition Assay GI50=0.0051 μM 19394218
A549 Growth Inhibition Assay GI50=0.003 μM 19394218
A431 Growth Inhibition Assay GI50=0.0012 μM 19394218
PA1 Cytotoxic Assay 10 μM 72 h IC50=0.63 μM 19361894
HBL100 Cytotoxic Assay 10 μM 72 h IC50=0.24 μM 19361894
ECV304 Cytotoxic Assay 10 μM 72 h Cytotoxicity 19361894
WTK1 Function Assay 0.1 μM 72 h Cell cycle arrest in human WTK1 cells expressing p53 M237I mutant assessed as accumulation at sub-G0/G1 phase 19349174
WTK1 Function Assay 25 μM 8 h Induction of p53 transcriptional activity in human WTK1 cells expressing p53 M237I mutant assessed as p21-Cip1/Waf1 expression 19349174
WTK1 Function Assay 25 μM 8 h Induction of p53 phosphorylation at Ser15 in human WTK1 cells expressing p53 M237I mutant 19349174
WTK1 Function Assay 0.1 μM 8 h Induction of p53 transcriptional activity in human WTK1 cells expressing p53 M237I mutant assessed as p21-Cip1/Waf1 expression 19349174
WTK1 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in human WTK1 cells expressing p53 M237I mutant assessed as increase in PARP cleavage 19349174
WTK1 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in human WTK1 cells expressing p53 M237I mutant assessed as decrease in pro-caspase 3 level 19349174
WTK1 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in human WTK1 cells expressing p53 M237I mutant assessed as increase in cleaved caspase 3 level 19349174
WTK1 Function Assay 0.1 μM 8 h Induction of p53 phosphorylation at Ser15 in human WTK1 cells expressing p53 M237I mutant 19349174
TK6 Function Assay 25 μM 8 h Induction of p53 transcriptional activity in human TK6 cells expressing wild type p53 assessed as p21-Cip1/Waf1 expression 19349174
TK6 Function Assay 25 μM 8 h Induction of p53 phosphorylation at Ser15 in human TK6 cells expressing wild type p53 19349174
TK6 Function Assay 0.1 μM 72 h Cell cycle arrest in human TK6 cells expressing wild type p53 assessed as accumulation at sub-G0/G1 phase 19349174
TK6 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in PARP cleavage 19349174
TK6 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as decrease in pro-caspase 3 level 19349174
TK6 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in cleaved caspase 3 level 19349174
TK6 Function Assay 0.1 μM 8 h Induction of p53 transcriptional activity in human TK6 cells expressing wild type p53 assessed as p21-Cip1/Waf1 expression 19349174
TK6 Function Assay 0.1 μM 8 h Induction of p53 phosphorylation at Ser15 in human TK6 cells expressing wild type p53 19349174
NH32 Growth Inhibition Assay 0.1 μM 72 h Cell cycle arrest in p53 deficient human NH32 cells assessed as accumulation at sub-G0/G1 phase 19349174
NH32 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in p53 deficient human NH32 cells assessed as increase in PARP cleavage 19349174
NH32 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in p53 deficient human NH32 cells assessed as decrease in pro-caspase 3 level 19349174
NH32 Apoptosis Assay 0.1 μM 8 h Induction of apoptosis in p53 deficient human NH32 cells assessed as increase in cleaved caspase 3 level 19349174
SMMC-7541 Cytotoxic Assay 72 h IC50=0.0037 μM 19285863
T47D Apoptosis Assay 10 μM 48 h DMSO Induction of apoptosis assessed as caspase activation with EC50 of 0.57 μM 19282188
SNU398 Apoptosis Assay 10 μM 48 h DMSO Induction of apoptosis assessed as caspase activation with EC50 of 0.39 μM 19282188
MEF Cytotoxic Assay 72 h IC50=3.4 μM 19186946
Hs888Lu Cytotoxic Assay 72 h IC50=1.4 μM 19186946
HL60 Cytotoxic Assay 100 μM 72 h DMSO IC50=0.018 μM 19136263
A2780/DX3 Function Assay 10 μM 2 h saline Reversal of P-gp 170-mediated multidrug resistance assessed as increase in intracellular doxorubicin accumulation 19093883
XF498 Growth Inhibition Assay 96 h DMSO IC50=0.16 μM 19053767
MT4 Growth Inhibition Assay 96 h DMSO IC50=0.003 μM 19053767
HT-29 Growth Inhibition Assay 96 h DMSO IC50=0.002 μM 19053767
HT-29 Cytotoxic Assay 72 h DMSO IC50=0.018 μM 19028425
Bel7402 Cytotoxic Assay 72 h DMSO IC50=0.021 μM 19028425
DU145 Cytotoxic Assay 25 μg/mL 72 h IC50=0.0039 μM 18829316
MRC5 Cytotoxic Assay 72 h IC50=0.1 μM 18783950
Jurkat Cytotoxic Assay 72 h IC50=0.03 μM 18783950
AW8507 Cytotoxic Assay 100 μM 48 h GI50=0.17 μM 18657979
AW13516 Cytotoxic Assay 100 μM 48 h GI50=0.1 μM 18657979
SK-MEL-2 Growth Inhibition Assay 72 h GI50=0.11 μM 18585035
L1210 Function Assay 0.5 μg/mL 12 h water Cell cycle arrest in mouse L1210 cells by accumulation at G2/M phase 18508273
LLC Cytotoxic Assay 72 h DMSO IC50=0.01 μM 18440233
Colon 26-L5 Cytotoxic Assay 72 h DMSO IC50=0.01 μM 18440233
MCF7/DX Cytotoxic Assay 24 h water Cytotoxicity against human doxorubicin-resistant MCF7/Dx cells with IC50 of 5.3 μM 18429610
Caco2 Function Assay 50 nM 48 h water Decrease in cyclin A expression 18429610
SNU638 Cytotoxic Assay 72 h DMSO IC50=0.052 μM 18321715
HT1080 Cytotoxic Assay 72 h DMSO IC50=0.022 μM 18321715
Hep2 Cytotoxic Assay 24 h DMSO IC50=0.42 μM 18281125
A375 Cytotoxic Assay 24 h DMSO IC50=0.01 μM 18281125
K/VP.5 Growth Inhibition Assay 72 h DMSO Growth inhibition of human K/VP.5 cells with IC50 of 0.41 μM 18258442
PC3M Growth Inhibition Assay 72 h DMSO IC50=1.11 μM 18247573
SJSA1 Cytotoxic Assay 1 μM 6 h Cytotoxicity against human SJSA1 cells expressing GRP78 with IC50 of 0.0062 μM 18243696
HepG2 Cytotoxic Assay 100 μM 72 h IC50=0.07 μM 18181575
U373MG Growth Inhibition Assay 24 h DMSO Growth inhibition of human U373MG cells containing UhiCE expressing plasmid with IC50 of 0.19953 μM 18173233
U373MG Growth Inhibition Assay 24 h DMSO Growth inhibition of human U373MG cells containing UhCE1 expressing plasmid with IC50 of 0.15849 μM 18173233
U373MG Growth Inhibition Assay 24 h DMSO Growth inhibition of human U373MG cells containing U373IRES plasmid with IC50 of 0.15849 μM 18173233
SNU638 Growth Inhibition Assay 72 h IC50=0.07 μM 18063366
SF268 Growth Inhibition Assay 72 h DMSO IC50=0.04 μM 18052326
W301 Growth Inhibition Assay 50 mM 48 h DMSO Growth inhibition of Saccharomyces cerevisiae W301 with IC50 of 10 μM 18040043
Daudi Cytotoxic Assay 100 μM 96 h Cytotoxicity against human Daudi cells under deem light with IC50 of 0.3 μM 17993275
2780.9S Cytotoxic Assay 100 μM 96 h Cytotoxicity against human 2780.9S cells under deem light with IC50 of 15 μM 17993275
MCF7 Growth Inhibition Assay 100 μM 72 h DMSO IC50=0.0007 μM 17949859
KB3.1 Growth Inhibition Assay 100 μM 72 h DMSO IC50=0.0004 μM 17949859
WI38 Growth Inhibition Assay 100 μM 72 h IC50=0.1 μM 17935309
MIAPaCa2 Growth Inhibition Assay 100 μM 72 h IC50=0.024 μM 17935309
UACC257 Growth Inhibition Assay 48 h IC50=0.20893 μM 17696516
RXF393 Growth Inhibition Assay 48 h IC50=0.17783 μM 17696516
IGROVI Growth Inhibition Assay 48 h IC50=0.10965 μM 17696516
BxPc3 Growth Inhibition Assay 3 h IC50=0.31623 μM 17696516
PC3 Function Assay 20 nM 72 h Induction of senescence in human PC3 cells 17658777
UO31 Cytotoxic Assay 72 h IC50=0.1 μM 17656091
DLD1 Cytotoxic Assay 72 h IC50=0.1 μM 17656091
UACC62 Growth Inhibition Assay 48 h DMSO GI50=0.094 μM 17614292
LNcaP Cytotoxic Assay DMSO ED50=0.04 μM 17591444
1A9 Cytotoxic Assay DMSO ED50=0.02 μM 17591444
ZR-751 Cytotoxic Assay 72 h DMSO IC50=0.04 μM 17585747
BGC823 Cytotoxic Assay 48 h IC50=0.35 μM 17583953
2780AD Growth Inhibition Assay 10 μM Growth inhibition of multidrug-resistant human 2780AD cells with IC50 of 0.298 μM 17490878
KB-VIN Cytotoxic Assay 72 h DMSO Cytotoxicity against human multidrug-resistant KB-VIN cells with EC50 of 1.7 μM 17378530
MeVo Cytotoxic Assay 48 h water IC50=0.82 μM 17375902
CEM/VM1 Cytotoxic Assay 72 h DMSO Cytotoxicity against teniposide-resistant CEM/VM1 cells with IC50 of 0.55 μM 17323939
CEM/VLB100 Cytotoxic Assay 72 h DMSO Cytotoxicity against CEM/VLB100 cells with IC50 of 3.71 μM 17323939
K562I/S9 Growth Inhibition Assay 72 h DMSO Antiproliferative activity against human multidrug-resistant K562i/S9 cells expressing Pgp with IC50 of 2 μM 17276690
2780AD Cytotoxic Assay 10 μM Cytotoxicity againt multidrug-resistant human 2780AD cells with IC50 of 0.909 μM 17239597
TRAMP-C2H Growth Inhibition Assay 72 h water GI50=0.0158 μM 17181166
TRAMP-C1A Growth Inhibition Assay 72 h water GI50=0.0204 μM 17181166
K562 Growth Inhibition Assay 48 h DMSO/methanol IC50=0.01 μM 17181164
MDA435/LCC6 Growth Inhibition Assay 4 d DMSO IC50=0.3 μM 17154505
MDA-MB-231 Cytotoxic Assay 72 h DMSO IC50=0.03 μM 17141923
A2780 Growth Inhibition Assay 1 μM 4 d DMSO Inhibition of doxorubicin-resistant A2780 cell growth with IC50 of 0.061 μM 17125254
A2780 Growth Inhibition Assay 1 μM 4 d DMSO Inhibition of A2780 cell growth with IC50 of 0.003 μM 17125254
Vero Cytotoxic Assay 24 h DMSO IC50=0.50119 μM 17125253
SK-HEP-1 Growth Inhibition Assay 24 h DMSO IC50=0.05012 μM 17125253
SHP77 Growth Inhibition Assay 24 h DMSO IC50=0.12589 μM 17125253
H9c2 Growth Inhibition Assay 24 h DMSO IC50=0.01995 μM 17125253
AGS Cytotoxic Assay IC50=0.31 μM 17125240
HA22T Cytotoxic Assay 72 h DMSO IC50=0.31 μM 17107806
HL60/ADR Cytotoxic Assay 1 mM 72 h DMSO Cytotoxicity against adriamycin-resistant HL60/ADR cells expressing MRP1 with IC50 of 2 μM 17069934
BC Cytotoxic Assay IC50=0.288 μM 16933890
Wil2-NS Growth Inhibition Assay 96 h DMSO IC50=0.02 μM 16913700
G361 Growth Inhibition Assay 96 h DMSO IC50=0.09 μM 16913700
C8166 Growth Inhibition Assay 96 h DMSO IC50=0.02 μM 16913700
ACHN Growth Inhibition Assay 96 h DMSO IC50=0.001 μM 16913700
5637 Growth Inhibition Assay 96 h DMSO IC50=0.02 μM 16913700
MCF7 Function Assay 0.5 μg/mL 24 h DMSO Inhibition of p53-mediated transactivation 16862141
VA13 Growth Inhibition Assay 48 h DMSO IC50=0.22 μM 16499322
MESSA/DX5 Cytotoxic Assay Cytotoxicity against multidrug-resistant MES-SA/Dx5 cells with IC50 of 1.56 μM 16169719
MES-SA Cytotoxic Assay IC50=0.016 μM 16169719
HSG Cytotoxic Assay 24 h CC50=1.9 μM 15745812
HSC-2 Cytotoxic Assay 24 h CC50=0.68 μM 15745812
NCI-H69 Cytotoxic Assay 6 d IC50=0.0113 μM 15743178
VA13 Cytotoxic Assay 48 h DMSO IC50=0.38 μM 15730243
MeVo Growth Inhibition Assay 24 h water IC50=0.82 μM 15715481
WI38 Cytotoxic Assay 48 h DMSO IC50=0.3 μM 15620238
Rtx6 Growth Inhibition Assay 4 h DMSO Growth inhibition of ER expressing Rtx6 cells 15588086
MEL-28 Cytotoxic Assay IC50=0.03 μM 15225700
Col2 Cytotoxic Assay 72 h DMSO IC50=0.52 μM 15177438
U937/GTB Cytotoxic Assay 72 h IC50=0.1 μM 14987049
RPMI8226 Cytotoxic Assay 72 h IC50=0.1 μM 14987049
T47D Cytotoxic Assay 72 h IC50=0.007 μM 14980672
MD-MB468 Cytotoxic Assay 72 h IC50=0.007 μM 14980672
TRAMP-C2G Growth Inhibition Assay 72 h IC50=0.0287 μM 14971910
TRAMP-C2D Growth Inhibition Assay 72 h IC50=0.0465 μM 14971910
MDA-MB-435 Growth Inhibition Assay 4 h DMSO IC50=0.15 μM 14971899
PANC-1 Growth Inhibition Assay 72 h DMSO GI50=3.5 μM 14971893
MEL-28 Growth Inhibition Assay 72 h DMSO GI50=3.1 μM 14971893
LOVO Growth Inhibition Assay 72 h DMSO GI50=0.01 μM 14971893
LNcaP Growth Inhibition Assay 72 h DMSO GI50=0.02 μM 14971893
IGROV Growth Inhibition Assay 72 h DMSO GI50=4.4 μM 14971893
HeLa Growth Inhibition Assay 72 h DMSO GI50=0.01 μM 14971893
DU145 Growth Inhibition Assay 72 h DMSO GI50=0.02 μM 14971893
DuPRO Cytotoxic Assay EC50=1.8 μM 14667208
SF268 Cytotoxic Assay GI50=8.5 × 10-7 μg/mL 14640532
MCF7 Cytotoxic Assay GI50=8.0 × 10-7 μg/mL 14640532
H460 Cytotoxic Assay GI50=3.0 × 10-7 μg/mL 14640532
HT1080 Growth Inhibition Assay 72 h DMSO IC50=0.059 μM 14640513
Neuro2A Function Assay 3 ug/mL 24 h Neuritogenic activity assessed as morphological changes 14575440
RXF944L Growth Inhibition Assay 72 h DMSO IC50=0.06 μM 12852768
LXF629L Growth Inhibition Assay 72 h DMSO IC50=0.07 μM 12852768
LXF529L Growth Inhibition Assay 72 h DMSO IC50=0.03 μM 12852768
401NL Growth Inhibition Assay 72 h DMSO IC50=0.01 μM 12852768
L2987 Cytotoxic Assay IC50=0.3 μM 12798317
P388 Growth Inhibition Assay 72 h IC50=0.015 μM 12620081
Jurkat Growth Inhibition Assay 72 h IC50=0.0096 μM 12620081
8226/S Cytotoxic Assay 72 h DMSO Cytotoxity against 8226/S 12570378
8226/DOX1V Cytotoxic Assay 72 h DMSO Cytotoxity against 8226/DOX1V 12570378
LXFL529 Growth Inhibition Assay 36 h IC50=0.04 μM 12459020
L1210 Cytotoxic Assay 48 h DMSO IC50=0.025 μM 12443763
HET-SR-2SC-LNM Growth Inhibition Assay 72 h deionized water IC50=0.052 μM 12431060
2SC/20 Growth Inhibition Assay 72 h deionized water IC50=0.62 μM 12431060
Wil-NS Growth Inhibition Assay 96 h DMSO IC50=0.02 μM 12431049
Raji Growth Inhibition Assay 96 h DMSO IC50=0.03 μM 12431049
Hep-2 Growth Inhibition Assay 96 h DMSO IC50=0.04 μM 12431049
SK-MES-1 Cytotoxic Assay 6 d DMSO IC50=0.03 μM 12431048
SKMEL-28 Cytotoxic Assay 6 d DMSO IC50=0.06 μM 12431048
CRL7065 Cytotoxic Assay 6 d DMSO IC50=0.5 μM 12431048
UMUC3 Cytotoxic Assay IC50=0.0092 μM 12392727
U251 Cytotoxic Assay IC50=0.09 μM 12039588
H69P Growth Inhibition Assay 4 d IC50=0.027 μM 11806725
H69/LX4 Growth Inhibition Assay 4 d Inhibitory activity against drug resistant H69/LX4 cell overexpressing P-glycoprotein with IC50 of 0.137 μM 11806725
H69P Cytotoxic Assay 5-6 d IC50=0.0273 μM 11806724
COR-L23 Cytotoxic Assay 5-6 d IC50=0.0201 μM 11806724
HCT116 Growth Inhibition Assay GI50=0.023 μM 11755363
SKVLB1 Cytotoxic Assay 72 h DMSO Cytotoxicity against human multidrug-resistant SKVLB1 cell with IC50 of 2.2 μM 11754602
UACC62 Cytotoxic Assay 3-5 m DMSO GI50=0.094 μM 11678649
U87 Cytotoxic Assay 10 μM DMSO Cytotoxicity against U87 resistant cell with IC50 of 0.14 μM 11606141
U87 Cytotoxic Assay 10 μM DMSO Cytotoxicity against U87 sensitive cell with IC50 of 0.06 μM 11606141
U373 Cytotoxic Assay 10 μM DMSO Cytotoxicity against U373 sensitive cell with IC50 of 0.01 μM 11606141
T24 Cytotoxic Assay 10 μM DMSO Cytotoxicity against T24 sensitive cell with IC50 of 0.02 μM 11606141
LoVo Cytotoxic Assay 10 μM DMSO Cytotoxicity against LoVo sensitive cell with IC50 of 0.008 μM 11606141
J82 Cytotoxic Assay 10 μM DMSO Cytotoxicity against J82 sensitive cell with IC50 of 0.03 μM 11606141
CNS Growth Inhibition Assay 48 h GI50=0.064 μM 11473418
RENCA Growth Inhibition Assay 48 h IC50<0.01 μM 11454467
CH1 Cytotoxic Assay 96 h DMSO IC50=0.0063 μM 11123989
UA375 Cytotoxic Assay 24 h DMSO IC50=0.112 μM 10956214
OVCAR-3 Cytotoxic Assay 24 h DMSO IC50=0.035 μM 10956214
D40 Cytotoxic Assay 24 h DMSO IC50=1.172 μM 10956214
L1210 Cytotoxic Assay IC50=0.025 μM 10890167
ZR-75-1 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against ZR-75-1 cell (ER+,pgr+,mutant p53) with IC50 of 0.009 μM 10780913
T47D Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against T47D cell (ER+,mutant p53) with IC50 of 0.007 μM 10780913
SKBR-3 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against SKBR-3 cell (ER-amplified erB2,mutant p53) with IC50 of 0.02 μM 10780913
NCI-H647 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against NCI-H647 cell (mutant p53) with IC50 of 0.001 μM 10780913
NCI-H358 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against NCI-H358 cell (mutant p53) with IC50 of 0.13 μM 10780913
NCI-H322 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against NCI-H322 cell (mutant p53) with IC50 of 0.03 μM 10780913
NCI-H226 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against NCI-H226 cell (mutant p53) with IC50 of 0.008 μM 10780913
MDA-468 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against MDA-468 cell (ER-, amplified EGFR, mutant p53) with IC50 of 0.005 μM 10780913
MDA-231 Cytotoxic Assay 100 μM 48 h Saline Cytotoxicity against MDA-231 cell (ER-,EGFR+,mutant p53) with IC50 of 0.006 μM 10780913
H460pv8 Cytotoxic Assay 100 μM 48 h Saline IC50=0.004 μM 10780913
H460pv8/eto Cytotoxic Assay 100 μM 48 h Saline IC50=0.02 μM 10780913
U937 Function Assay 24 h DMSO Inhibits incorporation of [3H]thymidine with IC50 of 0.1 μM 10780911
T24 Growth Inhibition Assay IC50=0.64 μM 10698436
PC14 Growth Inhibition Assay IC50=1.9 μM 10698436
MKN-1 Growth Inhibition Assay IC50=0.64 μM 10698436
HMV-1 Growth Inhibition Assay IC50=0.28 μM 10698436
P388 Cytotoxic Assay 72 h GI50=0.012 μM 10691710
3Y1 Cytotoxic Assay 72 h GI50=0.0038 μM 10691710
PACA-2 Cytotoxic Assay 6 d ED50=0.0063 μM 10498214
K562R Cytotoxic Assay 72 h IC50=0.0156 μM 10479282
DU145 Cytotoxic Assay 72 h IC50=0.0528 μM 10479282
MEL-AC Cytotoxic Assay 100 μM IC50=1.2 μM 10476861
HTB-54 Cytotoxic Assay 100 μM IC50=1.1 μM 10476861
KB Growth Inhibition Assay 4 d DMSO Antiproliferative activity against drug-resistant KBV20C with IC50 of 0.4 μM 10411476
KB Growth Inhibition Assay 4 d DMSO Antiproliferative activity against drug-resistant KBMDR with IC50 of 0.5 μM 10411476
KB Growth Inhibition Assay 4 d DMSO Antiproliferative activity against drug-resistant KBCampwith IC50 of 0.06 μM 10411476
KB Growth Inhibition Assay 4 d DMSO Antiproliferative activity against drug-resistant KB7D with IC50 of 0.65 μM 10411476
CHO-K1 Growth Inhibition Assay 4 d DMSO IC50=0.4 μM 10411476
CCRF-SB Growth Inhibition Assay 4 d DMSO IC50=0.01 μM 10411476
MDA-MB-361 Cytotoxic Assay 1 h DMSO Cytotoxicity against MDA MB 361 expressing carboxypeptidase stCPG2 with IC50 of 0.018 μM 10395490
MDA-MB-361 Cytotoxic Assay 1 h DMSO Cytotoxicity against MDA-MB-361 expressing LacZ with IC50 of 0.012 μM 10395490
SF-295 Cytotoxic Assay 72 h IC50=0.035 μM 9873661
HOP62 Cytotoxic Assay 72 h IC50=0.004 μM 9873661
PC14 Cytotoxic Assay 4 d DMSO IC50=0.29 μM 9822542
Panc02 Growth Inhibition Assay 10 μM 6 d IC50=0.065 μM 9526570
CHO Growth Inhibition Assay 10 μM 6 d IC50=0.06 μM 9526570
CA755 Growth Inhibition Assay 10 μM 6 d IC50=0.014 μM 9526570
MCF7/VP16 Cytotoxic Assay 50 μg/mL 72 h IC50=14.2 μM 9022792
SKVLB Cytotoxic Assay 72 h IC50=6.54 μM 9003520
C6 Cytotoxic Assay 2.5 mg/mL 5 h DMSO Cytotoxicity assessed as cell release 8988604
C6 Function Assay 2.5 mg/mL 4 h DMSO Inhibition of tubulin polymerization 8988604
C6 Cytotoxic Assay 2.5 mg/mL 72 h DMSO Cytotoxicity against rat C6 cells at 50 ug/mL to 2.5 mg/mL 8988604
MCF Function Assay Reversal of P-gp-mediated multidrug resistance assessed as enhancement in cytotoxicity of adriamycin 8984151
WiDr Cytotoxic Assay Activity against sensitive WiDr cell with IC50 of 0.053 μM 8960558
MXF7 Cytotoxic Assay Antitumor activity against doxorubicin-resistant MXF7 with IC50 of 1.172 μM 8960558
MXF7 Cytotoxic Assay Antitumor activity against MXF7 with IC50 of 0.028 μM 8960558
MXF7 Cytotoxic Assay Antitumor activity against sensitive MXF7 with IC50 of 0.028 μM 8960558
A2780-DX5 Cytotoxic Assay Cytotoxicity against doxorubicin-resistant A2780-DX5 with IC50 of 0.357 μM 8831755
A2780-CP3 Cytotoxic Assay Cytotoxicity against A2780-CP3 with IC50 of 0.056 μM 8831755
A2780-C25 Cytotoxic Assay Cytotoxicity against A2780-C25 with IC50 of 0.063 μM 8831755
AUC375 Growth Inhibition Assay IC50=0.112 μM 8648600
SKVLB Cytotoxic Assay IC50=5.6 μM 8576914
EAC Cytotoxic Assay 72 h IC50=0.35 μM 8350087
C38 Cytotoxic Assay IC50=0.01 μM 8057291
LOX Cytotoxic Assay IC50=0.042 μM 7853331
H2981 Cytotoxic Assay IC50=0.5 μM 7731023
EMT6 Growth Inhibition Assay 0.5 μM 1 h Inhibition of proliferation by measuring for surviving fractions with ED50 of 0.0001 μM 7452674
HT-29 Growth Inhibition Assay 0.01 μg 48 h Antiproliferative activity 2778449
KBM-3 Growth Inhibition Assay IC50=0.026 μM 1995877
MLM Cytotoxic Assay ED50=0.13 μM 1875350
SKMEL-5 Growth Inhibition Assay ED50=3.2 μM 1613753
T-MT4 Growth Inhibition Assay ID50=0.01 μM 1548681
T-H9 Growth Inhibition Assay ID50=0.01 μM 1548681
T-C8166 Growth Inhibition Assay ID50=0.01 μM 1548681
H9 Growth Inhibition Assay Inhibition of H9 cells chronically infected with the HIV-1 (H9/IIIB) with ID50 of 0.01 μM 1548681
N417 Growth Inhibition Assay IC50=0.23 μM 1479585
H69 Growth Inhibition Assay IC50=0.87 μM 1479585
MCF7/ADR Growth Inhibition Assay IC50=3.1 μM 1447730
8226/ADR Growth Inhibition Assay IC50=0.56 μM 1447730
8226 Growth Inhibition Assay IC50=0.033 μM 1447730
CHO Growth Inhibition Assay IC50=0.06 μM 1354750
Yoshida sarcoma Function Assay Inhibition of [3H]TdR incorporation with IC50 of 0.02 μM 1322986
L1210 Function Assay Inhibition of RNA synthesis with ED50 of 0.58 μM 490536
A431 Cytotoxic Assay IC50=0.00135 μM 24890652
HT-29 Function Assay 25 μM 24 h Inhibition of MRP3-mediated drug resistance in doxorubicin-resistant human HT-29 cells assessed as increase in drug accumulation 24900337
HT-29 Function Assay 5 μM 24 h Inhibition of MRP3 in doxorubicin-resistant human HT-29 cells assessed as nitration of tyrosine residues 24900337
HT-29 Function Assay 5 μM 1 h Inhibition of MRP3-mediated drug resistance in doxorubicin-resistant human HT-29 cells assessed as increase in drug accumulation 24900337
HT-29 Function Assay 5 μM 1 h Induction of nitrite production in doxorubicin-resistant human HT-29 cells 24900337
NAR Function Assay 5 μM 2 h Drug uptake in doxorubicin-resistant human NAR cell plasma membrane 24900344
NAR Cytotoxic Assay 10 μM 24 h Cytotoxicity assessed as induction of cell death 24900344
NAR Cytotoxic Assay 100 μM 24 h Cytotoxicity against doxorubicin-resistant human NAR cells assessed as cell viability 24900344
DA-3 Cytotoxic Assay 60 μM 24 h IC50=4 μM 24900668
DA-3 Function Assay 10 μM 10 h Cellular uptake in mouse DA-3 cell mitochondria 24900668
DA-3 Function Assay 10 μM 10 h Cellular uptake in mouse DA-3 cell lysosome 24900668
DA-3 Function Assay 10 μM 10 h Cellular uptake in mouse DA-3 cell nucleus 24900668
YOYO1 Function Assay Displacement of YOYO1 from phage lambda DNA with IC50 of 0.6 μM 24900668
KCL22 Growth Inhibition Assay 48 h IC50=1.8 μM 24941129
Saos2 Growth Inhibition Assay 40 μM 24 h DMSO IC50=0.33 μM 24941130
IMR32 Cytotoxic Assay 250 μM 48 h DMSO IC50=0.0051 μM 24996140
NTERA-S-cl-D1 Growth Inhibition Assay IC50=1.37 nM SANGER
EW-16 Growth Inhibition Assay IC50=1.91 nM SANGER
HUTU-80 Growth Inhibition Assay IC50=2.12 nM SANGER
KS-1 Growth Inhibition Assay IC50=3.44 nM SANGER
HT-144 Growth Inhibition Assay IC50=3.51 nM SANGER
MFH-ino Growth Inhibition Assay IC50=3.99 nM SANGER
LC-2 Growth Inhibition Assay IC50=5.07 nM SANGER
SW982 Growth Inhibition Assay IC50=6.05 nM SANGER
ES4 Growth Inhibition Assay IC50=6.11 nM SANGER
KGN Growth Inhibition Assay IC50=6.34 nM SANGER
RH-1 Growth Inhibition Assay IC50=6.73 nM SANGER
IGROV-1 Growth Inhibition Assay IC50=7.2 nM SANGER
KYSE-270 Growth Inhibition Assay IC50=7.21 nM SANGER
TE-8 Growth Inhibition Assay IC50=7.5 nM SANGER
Daoy Growth Inhibition Assay IC50=8.07 nM SANGER
REH Growth Inhibition Assay IC50=8.11 nM SANGER
786-0 Growth Inhibition Assay IC50=8.47 nM SANGER
A375 Growth Inhibition Assay IC50=9.17 nM SANGER
EW-13 Growth Inhibition Assay IC50=9.63 nM SANGER
MKN1 Growth Inhibition Assay IC50=9.86 nM SANGER
MV-4-11 Growth Inhibition Assay IC50=10.03 nM SANGER
ESS-1 Growth Inhibition Assay IC50=11.09 nM SANGER
PSN1 Growth Inhibition Assay IC50=11.22 nM SANGER
MCF7 Growth Inhibition Assay IC50=11.65 nM SANGER
A427 Growth Inhibition Assay IC50=11.81 nM SANGER
NCI-H1651 Growth Inhibition Assay IC50=11.83 nM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=11.83 nM SANGER
DU-4475 Growth Inhibition Assay IC50=12.1 nM SANGER
SK-LU-1 Growth Inhibition Assay IC50=12.54 nM SANGER
NCI-H460 Growth Inhibition Assay IC50=12.7 nM SANGER
A204 Growth Inhibition Assay IC50=12.88 nM SANGER
AGS Growth Inhibition Assay IC50=13.27 nM SANGER
NCI-H2228 Growth Inhibition Assay IC50=13.48 nM SANGER
HGC-27 Growth Inhibition Assay IC50=13.56 nM SANGER
RPMI-2650 Growth Inhibition Assay IC50=13.69 nM SANGER
ES1 Growth Inhibition Assay IC50=13.72 nM SANGER
MEL-JUSO Growth Inhibition Assay IC50=14.5 nM SANGER
HT-1080 Growth Inhibition Assay IC50=14.82 nM SANGER
OCUB-M Growth Inhibition Assay IC50=15.15 nM SANGER
23132-87 Growth Inhibition Assay IC50=15.42 nM SANGER
KYSE-510 Growth Inhibition Assay IC50=15.48 nM SANGER
ST486 Growth Inhibition Assay IC50=15.53 nM SANGER
639-V Growth Inhibition Assay IC50=15.91 nM SANGER
COLO-679 Growth Inhibition Assay IC50=15.97 nM SANGER
CTV-1 Growth Inhibition Assay IC50=16.07 nM SANGER
BFTC-905 Growth Inhibition Assay IC50=16.18 nM SANGER
SW954 Growth Inhibition Assay IC50=16.93 nM SANGER
CAL-51 Growth Inhibition Assay IC50=17.32 nM SANGER
SW1710 Growth Inhibition Assay IC50=17.4 nM SANGER
HCC2998 Growth Inhibition Assay IC50=17.44 nM SANGER
A2058 Growth Inhibition Assay IC50=17.65 nM SANGER
HCE-4 Growth Inhibition Assay IC50=18.07 nM SANGER
MEL-HO Growth Inhibition Assay IC50=18.3 nM SANGER
SNG-M Growth Inhibition Assay IC50=18.32 nM SANGER
LS-123 Growth Inhibition Assay IC50=18.46 nM SANGER
NALM-6 Growth Inhibition Assay IC50=18.63 nM SANGER
NCI-H810 Growth Inhibition Assay IC50=18.76 nM SANGER
YKG-1 Growth Inhibition Assay IC50=18.77 nM SANGER
647-V Growth Inhibition Assay IC50=18.81 nM SANGER
ONS-76 Growth Inhibition Assay IC50=18.91 nM SANGER
697 Growth Inhibition Assay IC50=19.09 nM SANGER
RS4-11 Growth Inhibition Assay IC50=19.14 nM SANGER
8505C Growth Inhibition Assay IC50=19.56 nM SANGER
SK-UT-1 Growth Inhibition Assay IC50=19.96 nM SANGER
DOHH-2 Growth Inhibition Assay IC50=19.99 nM SANGER
NCCIT Growth Inhibition Assay IC50=20.13 nM SANGER
LCLC-103H Growth Inhibition Assay IC50=20.54 nM SANGER
CAL-12T Growth Inhibition Assay IC50=20.65 nM SANGER
QIMR-WIL Growth Inhibition Assay IC50=20.72 nM SANGER
SBC-5 Growth Inhibition Assay IC50=20.74 nM SANGER
769-P Growth Inhibition Assay IC50=20.76 nM SANGER
A431 Growth Inhibition Assay IC50=20.87 nM SANGER
KE-37 Growth Inhibition Assay IC50=21.05 nM SANGER
ES8 Growth Inhibition Assay IC50=21.07 nM SANGER
22RV1 Growth Inhibition Assay IC50=21.24 nM SANGER
LOUCY Growth Inhibition Assay IC50=21.32 nM SANGER
J82 Growth Inhibition Assay IC50=21.34 nM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=21.58 nM SANGER
MG-63 Growth Inhibition Assay IC50=22.08 nM SANGER
8-MG-BA Growth Inhibition Assay IC50=22.12 nM SANGER
BPH-1 Growth Inhibition Assay IC50=22.12 nM SANGER
RKO Growth Inhibition Assay IC50=22.28 nM SANGER
HMV-II Growth Inhibition Assay IC50=22.6 nM SANGER
NCI-H727 Growth Inhibition Assay IC50=22.79 nM SANGER
MOLT-4 Growth Inhibition Assay IC50=22.86 nM SANGER
NCI-H2342 Growth Inhibition Assay IC50=22.91 nM SANGER
MZ1-PC Growth Inhibition Assay IC50=23.81 nM SANGER
TE-15 Growth Inhibition Assay IC50=24.14 nM SANGER
SR Growth Inhibition Assay IC50=24.41 nM SANGER
CCRF-CEM Growth Inhibition Assay IC50=24.52 nM SANGER
SIG-M5 Growth Inhibition Assay IC50=25.69 nM SANGER
SK-PN-DW Growth Inhibition Assay IC50=25.72 nM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=25.86 nM SANGER
SW620 Growth Inhibition Assay IC50=26.63 nM SANGER
HSC-2 Growth Inhibition Assay IC50=26.78 nM SANGER
CAL-148 Growth Inhibition Assay IC50=26.9 nM SANGER
COLO-205 Growth Inhibition Assay IC50=26.99 nM SANGER
EoL-1-cell Growth Inhibition Assay IC50=27.78 nM SANGER
KYSE-150 Growth Inhibition Assay IC50=27.78 nM SANGER
G-361 Growth Inhibition Assay IC50=28.88 nM SANGER
PANC-03-27 Growth Inhibition Assay IC50=28.16 nM SANGER
NCI-H2030 Growth Inhibition Assay IC50=28.26 nM SANGER
NCI-H441 Growth Inhibition Assay IC50=28.42 nM SANGER
A388 Growth Inhibition Assay IC50=28.46 nM SANGER
BHY Growth Inhibition Assay IC50=28.88 nM SANGER
KALS-1 Growth Inhibition Assay IC50=29.33 nM SANGER
NKM-1 Growth Inhibition Assay IC50=29.47 nM SANGER
BB30-HNC Growth Inhibition Assay IC50=29.85 nM SANGER
G-401 Growth Inhibition Assay IC50=30.2 nM SANGER
EW-7 Growth Inhibition Assay IC50=30.63 nM SANGER
CAN Growth Inhibition Assay IC50=31.12 nM SANGER
M059J Growth Inhibition Assay IC50=31.37 nM SANGER
SK-MES-1 Growth Inhibition Assay IC50=31.5 nM SANGER
5637 Growth Inhibition Assay IC50=31.87 nM SANGER
MKN28 Growth Inhibition Assay IC50=31.91 nM SANGER
COR-L23 Growth Inhibition Assay IC50=31.96 nM SANGER
CAL-27 Growth Inhibition Assay IC50=32.57 nM SANGER
CAL-62 Growth Inhibition Assay IC50=32.79 nM SANGER
C-33-A Growth Inhibition Assay IC50=32.89 nM SANGER
RT-112 Growth Inhibition Assay IC50=32.92 nM SANGER
KU812 Growth Inhibition Assay IC50=33.24 nM SANGER
C8166 Growth Inhibition Assay IC50=33.31 nM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=33.36 nM SANGER
NEC8 Growth Inhibition Assay IC50=33.61 nM SANGER
EB2 Growth Inhibition Assay IC50=33.73 nM SANGER
COLO-680N Growth Inhibition Assay IC50=33.87 nM SANGER
IGR-1 Growth Inhibition Assay IC50=33.83 nM SANGER
MZ2-MEL Growth Inhibition Assay IC50=33.92 nM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=34.24 nM SANGER
IMR-5 Growth Inhibition Assay IC50=34.68 nM SANGER
CHP-212 Growth Inhibition Assay IC50=34.96 nM SANGER
CCF-STTG1 Growth Inhibition Assay IC50=35.5 nM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=35.61 nM SANGER
HLE Growth Inhibition Assay IC50=35.8 nM SANGER
HOP-62 Growth Inhibition Assay IC50=35.88 nM SANGER
LB1047-RCC Growth Inhibition Assay IC50=35.97 nM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=36.25 nM SANGER
HT-29 Growth Inhibition Assay IC50=36.57 nM SANGER
HC-1 Growth Inhibition Assay IC50=37.32 nM SANGER
TE-5 Growth Inhibition Assay IC50=37.48 nM SANGER
NCI-H1299 Growth Inhibition Assay IC50=37.59 nM SANGER
CHL-1 Growth Inhibition Assay IC50=37.73 nM SANGER
NCI-H2122 Growth Inhibition Assay IC50=37.9 nM SANGER
DEL Growth Inhibition Assay IC50=38.44 nM SANGER
ES5 Growth Inhibition Assay IC50=39.22 nM SANGER
CESS Growth Inhibition Assay IC50=39.36 nM SANGER
NCI-H719 Growth Inhibition Assay IC50=39.65 nM SANGER
A3-KAW Growth Inhibition Assay IC50=40.14 nM SANGER
KP-4 Growth Inhibition Assay IC50=40.77 nM SANGER
NCI-H358 Growth Inhibition Assay IC50=41.08 nM SANGER
HCC38 Growth Inhibition Assay IC50=42.5 nM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=43.66 nM SANGER
NCI-H292 Growth Inhibition Assay IC50=43.76 nM SANGER
PA-1 Growth Inhibition Assay IC50=44.48 nM SANGER
CAL-85-1 Growth Inhibition Assay IC50=44.52 nM SANGER
KYSE-450 Growth Inhibition Assay IC50=44.71 nM SANGER
IST-MEL1 Growth Inhibition Assay IC50=44.84 nM SANGER
Ca-Ski Growth Inhibition Assay IC50=44.84 nM SANGER
OCI-AML2 Growth Inhibition Assay IC50=45.05 nM SANGER
NUGC-3 Growth Inhibition Assay IC50=45.2 nM SANGER
HOS Growth Inhibition Assay IC50=45.29 nM SANGER
NB1 Growth Inhibition Assay IC50=45.99 nM SANGER
A253 Growth Inhibition Assay IC50=46.12 nM SANGER
NCI-H209 Growth Inhibition Assay IC50=48.73 nM SANGER
MC-CAR Growth Inhibition Assay IC50=48.74 nM SANGER
NCI-H661 Growth Inhibition Assay IC50=49.03 nM SANGER
SF295 Growth Inhibition Assay IC50=49.08 nM SANGER
GP5d Growth Inhibition Assay IC50=49.12 nM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=49.27 nM SANGER
ACHN Growth Inhibition Assay IC50=49.34 nM SANGER
NCI-H2087 Growth Inhibition Assay IC50=49.42 nM SANGER
SW48 Growth Inhibition Assay IC50=49.72 nM SANGER
NCI-H526 Growth Inhibition Assay IC50=49.96 nM SANGER
Ca9-22 Growth Inhibition Assay IC50=50.07 nM SANGER
SK-OV-3 Growth Inhibition Assay IC50=50.12 nM SANGER
KYSE-140 Growth Inhibition Assay IC50=50.42 nM SANGER
BE-13 Growth Inhibition Assay IC50=51.02 nM SANGER
ES7 Growth Inhibition Assay IC50=51.4 nM SANGER
IM-9 Growth Inhibition Assay IC50=51.43 nM SANGER
A101D Growth Inhibition Assay IC50=51.48 nM SANGER
CAPAN-1 Growth Inhibition Assay IC50=51.76 nM SANGER
NCI-H2009 Growth Inhibition Assay IC50=51.76 nM SANGER
NCI-H522 Growth Inhibition Assay IC50=51.93 nM SANGER
HuP-T4 Growth Inhibition Assay IC50=52.22 nM SANGER
BCPAP Growth Inhibition Assay IC50=52.5 nM SANGER
NCI-H1734 Growth Inhibition Assay IC50=53 nM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=53.22 nM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=53.46 nM SANGER
RPMI-8402 Growth Inhibition Assay IC50=53.86 nM SANGER
Calu-3 Growth Inhibition Assay IC50=55.98 nM SANGER
COR-L279 Growth Inhibition Assay IC50=56.95 nM SANGER
T84 Growth Inhibition Assay IC50=57.06 nM SANGER
P30-OHK Growth Inhibition Assay IC50=57.57 nM SANGER
CHP-126 Growth Inhibition Assay IC50=59.24 nM SANGER
KYSE-180 Growth Inhibition Assay IC50=59.75 nM SANGER
CAMG Growth Inhibition Assay IC50=59.96 nM SANGER
EW-1 Growth Inhibition Assay IC50=61.35 nM SANGER
OVCAR-8 Growth Inhibition Assay IC50=61.92 nM SANGER
HL-60 Growth Inhibition Assay IC50=62.56 nM SANGER
8305C Growth Inhibition Assay IC50=63.12 nM SANGER
IA-LM Growth Inhibition Assay IC50=63.54 nM SANGER
HCC2157 Growth Inhibition Assay IC50=63.95 nM SANGER
CTB-1 Growth Inhibition Assay IC50=64019 nM SANGER
NCI-H1437 Growth Inhibition Assay IC50=64.64 nM SANGER
U251 Growth Inhibition Assay IC50=64.89 nM SANGER
ALL-PO Growth Inhibition Assay IC50=65.03 nM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=65.86 nM SANGER
RPMI-6666 Growth Inhibition Assay IC50=65.99 nM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=67.11 nM SANGER
PF-382 Growth Inhibition Assay IC50=67.17 nM SANGER
GT3TKB Growth Inhibition Assay IC50=67.19 nM SANGER
SCC-3 Growth Inhibition Assay IC50=67.28 nM SANGER
LU-134-A Growth Inhibition Assay IC50=67.68 nM SANGER
CAL-33 Growth Inhibition Assay IC50=67.87 nM SANGER
MC-IXC Growth Inhibition Assay IC50=67.9 nM SANGER
CPC-N Growth Inhibition Assay IC50=68.4 nM SANGER
A2780 Growth Inhibition Assay IC50=68.79 nM SANGER
Daudi Growth Inhibition Assay IC50=68.96 nM SANGER
GI-1 Growth Inhibition Assay IC50=69.65 nM SANGER
SW962 Growth Inhibition Assay IC50=69.95 nM SANGER
MFE-296 Growth Inhibition Assay IC50=70.49 nM SANGER
H4 Growth Inhibition Assay IC50=71.56 nM SANGER
AN3-CA Growth Inhibition Assay IC50=72.32 nM SANGER
HCC1599 Growth Inhibition Assay IC50=72.54 nM SANGER
HuCCT1 Growth Inhibition Assay IC50=72.93 nM SANGER
Calu-1 Growth Inhibition Assay IC50=73.6 nM SANGER
DU-145 Growth Inhibition Assay IC50=73.73 nM SANGER
IST-SL2 Growth Inhibition Assay IC50=73.81 nM SANGER
HSC-3 Growth Inhibition Assay IC50=74.53 nM SANGER
HCC1806 Growth Inhibition Assay IC50=74.96 nM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=75.36 nM SANGER
HSC-4 Growth Inhibition Assay IC50=75.76 nM SANGER
NH-12 Growth Inhibition Assay IC50=76 nM SANGER
MDA-MB-468 Growth Inhibition Assay IC50=76.18 nM SANGER
TUR Growth Inhibition Assay IC50=76.32 nM SANGER
TE-1 Growth Inhibition Assay IC50=76.35 nM SANGER
CMK Growth Inhibition Assay IC50=77.42 nM SANGER
LB996-RCC Growth Inhibition Assay IC50=78.45 nM SANGER
NCI-H1650 Growth Inhibition Assay IC50=78.62 nM SANGER
DMS-273 Growth Inhibition Assay IC50=78.9 nM SANGER
NOS-1 Growth Inhibition Assay IC50=79.14 nM SANGER
NB69 Growth Inhibition Assay IC50=79.2 nM SANGER
SUP-T1 Growth Inhibition Assay IC50=79.72 nM SANGER
A172 Growth Inhibition Assay IC50=80.55 nM SANGER
TE-12 Growth Inhibition Assay IC50=81.06 nM SANGER
MKN45 Growth Inhibition Assay IC50=81.51 nM SANGER
LoVo Growth Inhibition Assay IC50=81.82 nM SANGER
SW1573 Growth Inhibition Assay IC50=82.81 nM SANGER
ETK-1 Growth Inhibition Assay IC50=83.01 nM SANGER
ABC-1 Growth Inhibition Assay IC50=83.45 nM SANGER
COLO-668 Growth Inhibition Assay IC50=84.47 nM SANGER
UM-UC-3 Growth Inhibition Assay IC50=86.02 nM SANGER
BC-1 Growth Inhibition Assay IC50=86.76 nM SANGER
PANC-10-05 Growth Inhibition Assay IC50=88.45 nM SANGER
ES3 Growth Inhibition Assay IC50=89.48 nM SANGER
TE-441-T Growth Inhibition Assay IC50=89.82 nM SANGER
KM-H2 Growth Inhibition Assay IC50=90.68 nM SANGER
SH-4 Growth Inhibition Assay IC50=92.11 nM SANGER
SF268 Growth Inhibition Assay IC50=92.42 nM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=93.26 nM SANGER
GI-ME-N Growth Inhibition Assay IC50=93.33 nM SANGER
JEG-3 Growth Inhibition Assay IC50=95.12 nM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=96.31 nM SANGER
K5 Growth Inhibition Assay IC50=96.9 nM SANGER
EFO-27 Growth Inhibition Assay IC50=97.44 nM SANGER
SW1783 Growth Inhibition Assay IC50=97.99 nM SANGER
CAL-39 Growth Inhibition Assay IC50=98.24 nM SANGER
LS-441N Growth Inhibition Assay IC50=99.06 nM SANGER
G-402 Growth Inhibition Assay IC50=99.09 nM SANGER
MES-SA Growth Inhibition Assay IC50=99.53 nM SANGER
FADU Growth Inhibition Assay IC50=102.18 nM SANGER
DJM-1 Growth Inhibition Assay IC50=102.25 nM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=102.5 nM SANGER
KYSE-410 Growth Inhibition Assay IC50=103.46 nM SANGER
NCI-H1618 Growth Inhibition Assay IC50=104.35 nM SANGER
AU565 Growth Inhibition Assay IC50=104.51 nM SANGER
SF126 Growth Inhibition Assay IC50=104.58 nM SANGER
MMAC-SF Growth Inhibition Assay IC50=106.48 nM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=107.95 nM SANGER
NCI-H596 Growth Inhibition Assay IC50=108.01 nM SANGER
LXF-289 Growth Inhibition Assay IC50=109.24 nM SANGER
HCC1569 Growth Inhibition Assay IC50=109.34 nM SANGER
NCI-H2170 Growth Inhibition Assay IC50=109.92 nM SANGER
ARH-77 Growth Inhibition Assay IC50=109.99 nM SANGER
BOKU Growth Inhibition Assay IC50=110.87 nM SANGER
SJSA-1 Growth Inhibition Assay IC50=111.05 nM SANGER
SW626 Growth Inhibition Assay IC50=111.71 nM SANGER
EHEB Growth Inhibition Assay IC50=112.59 nM SANGER
TE-10 Growth Inhibition Assay IC50=112.68 nM SANGER
MZ7-mel Growth Inhibition Assay IC50=112.84 nM SANGER
SAS Growth Inhibition Assay IC50=114.45 nM SANGER
TK10 Growth Inhibition Assay IC50=114.6 nM SANGER
SW13 Growth Inhibition Assay IC50=115.26 nM SANGER
HCC1937 Growth Inhibition Assay IC50=115.84 nM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=116.26 nM SANGER
OVCAR-5 Growth Inhibition Assay IC50=116.81 nM SANGER
SW837 Growth Inhibition Assay IC50=117.95 nM SANGER
BFTC-909 Growth Inhibition Assay IC50=118.48 nM SANGER
SW872 Growth Inhibition Assay IC50=120.81 nM SANGER
SF539 Growth Inhibition Assay IC50=121.72 nM SANGER
MLMA Growth Inhibition Assay IC50=122.08 nM SANGER
BL-41 Growth Inhibition Assay IC50=122.22 nM SANGER
LB647-SCLC Growth Inhibition Assay IC50=123.35 nM SANGER
NCI-H1703 Growth Inhibition Assay IC50=126.42 nM SANGER
KURAMOCHI Growth Inhibition Assay IC50=126.76 nM SANGER
ATN-1 Growth Inhibition Assay IC50=127.7 nM SANGER
SK-CO-1 Growth Inhibition Assay IC50=129.21 nM SANGER
RPMI-7951 Growth Inhibition Assay IC50=130.14 nM SANGER
NCI-H1648 Growth Inhibition Assay IC50=131.94 nM SANGER
NCI-H64 Growth Inhibition Assay IC50=132.65 nM SANGER
HT-3 Growth Inhibition Assay IC50=133.04 nM SANGER
NCI-H1770 Growth Inhibition Assay IC50=133.21 nM SANGER
NB13 Growth Inhibition Assay IC50=134.55 nM SANGER
NCI-H747 Growth Inhibition Assay IC50=135.02 nM SANGER
ML-2 Growth Inhibition Assay IC50=135.16 nM SANGER
CA46 Growth Inhibition Assay IC50=136.88 nM SANGER
ES6 Growth Inhibition Assay IC50=137.12 nM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=137.8 nM SANGER
NMC-G1 Growth Inhibition Assay IC50=139.13 nM SANGER
U-698-M Growth Inhibition Assay IC50=139.5 nM SANGER
LU-99A Growth Inhibition Assay IC50=146.55 nM SANGER
NCI-H748 Growth Inhibition Assay IC50=147.31 nM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=147.61 nM SANGER
SNB75 Growth Inhibition Assay IC50=148.65 nM SANGER
BB65-RCC Growth Inhibition Assay IC50=149.31 nM SANGER
NCI-H1355 Growth Inhibition Assay IC50=152.24 nM SANGER
SCC-25 Growth Inhibition Assay IC50=153.73 nM SANGER
OAW-42 Growth Inhibition Assay IC50=153.84 nM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=154.36 nM SANGER
WSU-NHL Growth Inhibition Assay IC50=154.58 nM SANGER
SNU-423 Growth Inhibition Assay IC50=155.34 nM SANGER
SBC-1 Growth Inhibition Assay IC50=156.4 nM SANGER
OVCAR-4 Growth Inhibition Assay IC50=156.78 nM SANGER
NCI-H2347 Growth Inhibition Assay IC50=158.34 nM SANGER
CAMA-1 Growth Inhibition Assay IC50=159.33 nM SANGER
GDM-1 Growth Inhibition Assay IC50=159.7 nM SANGER
KNS-81-FD Growth Inhibition Assay IC50=160.32 nM SANGER
no-10 Growth Inhibition Assay IC50=160.38 nM SANGER
NCI-H2052 Growth Inhibition Assay IC50=160.47 nM SANGER
DB Growth Inhibition Assay IC50=161.71 nM SANGER
A4-Fuk Growth Inhibition Assay IC50=162.48 nM SANGER
HCE-T Growth Inhibition Assay IC50=164.87 nM SANGER
HuP-T3 Growth Inhibition Assay IC50=165.55 nM SANGER
BC-3 Growth Inhibition Assay IC50=165.86 nM SANGER
RVH-421 Growth Inhibition Assay IC50=169.13 nM SANGER
COLO-800 Growth Inhibition Assay IC50=171.8 nM SANGER
OMC-1 Growth Inhibition Assay IC50=172.17 nM SANGER
SJRH30 Growth Inhibition Assay IC50=172.94 nM SANGER
HEL Growth Inhibition Assay IC50=175.15 nM SANGER
KLE Growth Inhibition Assay IC50=175.47 nM SANGER
MEG-01 Growth Inhibition Assay IC50=176.6 nM SANGER
OAW-28 Growth Inhibition Assay IC50=178.84 nM SANGER
RD Growth Inhibition Assay IC50=180.1 nM SANGER
HCC2218 Growth Inhibition Assay IC50=181.66 nM SANGER
OS-RC-2 Growth Inhibition Assay IC50=182.49 nM SANGER
HEC-1 Growth Inhibition Assay IC50=182.83 nM SANGER
SCC-4 Growth Inhibition Assay IC50=183.71 nM SANGER
ME-180 Growth Inhibition Assay IC50=186.08 nM SANGER
NB10 Growth Inhibition Assay IC50=188.09 nM SANGER
SCC-15 Growth Inhibition Assay IC50=188.24 nM SANGER
COR-L105 Growth Inhibition Assay IC50=188.92 nM SANGER
HT-1376 Growth Inhibition Assay IC50=189.01 nM SANGER
RPMI-8866 Growth Inhibition Assay IC50=192.13 nM SANGER
NCI-H2126 Growth Inhibition Assay IC50=192.2 nM SANGER
KARPAS-422 Growth Inhibition Assay IC50=193.41 nM SANGER
COLO-741 Growth Inhibition Assay IC50=194.58 nM SANGER
IPC-298 Growth Inhibition Assay IC50=196.21 nM SANGER
OE19 Growth Inhibition Assay IC50=200.18 nM SANGER
NCI-H1694 Growth Inhibition Assay IC50=200.26 nM SANGER
SW1990 Growth Inhibition Assay IC50=201.9 nM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=204.47 nM SANGER
LB831-BLC Growth Inhibition Assay IC50=206.25 nM SANGER
HCT-116 Growth Inhibition Assay IC50=207.39 nM SANGER
BxPC-3 Growth Inhibition Assay IC50=210.96 nM SANGER
HT-1197 Growth Inhibition Assay IC50=212.58 nM SANGER
GB-1 Growth Inhibition Assay IC50=212.73 nM SANGER
RPMI-8226 Growth Inhibition Assay IC50=213.37 nM SANGER
L-540 Growth Inhibition Assay IC50=213.49 nM SANGER
NCI-H1882 Growth Inhibition Assay IC50=215 nM SANGER
A673 Growth Inhibition Assay IC50=215.79 nM SANGER
NCI-H650 Growth Inhibition Assay IC50=217.61 nM SANGER
KM12 Growth Inhibition Assay IC50=218.15 nM SANGER
KP-N-YS Growth Inhibition Assay IC50=218.4 nM SANGER
COLO-684 Growth Inhibition Assay IC50=219.79 nM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=220.22 nM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=222.83 nM SANGER
NOMO-1 Growth Inhibition Assay IC50=224.43 nM SANGER
KYSE-70 Growth Inhibition Assay IC50=224.66 nM SANGER
NCI-H838 Growth Inhibition Assay IC50=224.73 nM SANGER
NY Growth Inhibition Assay IC50=228.49 nM SANGER
NCI-H2196 Growth Inhibition Assay IC50=229.15 nM SANGER
FTC-133 Growth Inhibition Assay IC50=229.37 nM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=229.82 nM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=230.3 nM SANGER
Detroit562 Growth Inhibition Assay IC50=230.72 nM SANGER
NCI-H2405 Growth Inhibition Assay IC50=234.1 nM SANGER
NCI-H2081 Growth Inhibition Assay IC50=234.27 nM SANGER
LB2241-RCC Growth Inhibition Assay IC50=235.11 nM SANGER
SNU-387 Growth Inhibition Assay IC50=236.08 nM SANGER
PC-14 Growth Inhibition Assay IC50=236.12 nM SANGER
CAS-1 Growth Inhibition Assay IC50=238.31 nM SANGER
TE-11 Growth Inhibition Assay IC50=240.88 nM SANGER
LC4-1 Growth Inhibition Assay IC50=240.89 nM SANGER
HH Growth Inhibition Assay IC50=241.46 nM SANGER
JVM-2 Growth Inhibition Assay IC50=242.17 nM SANGER
KNS-42 Growth Inhibition Assay IC50=242.67 nM SANGER
T-24 Growth Inhibition Assay IC50=245.48 nM SANGER
D-392MG Growth Inhibition Assay IC50=248.5 nM SANGER
KOSC-2 Growth Inhibition Assay IC50=248.71 nM SANGER
D-283MED Growth Inhibition Assay IC50=250.13 nM SANGER
BV-173 Growth Inhibition Assay IC50=250.77 nM SANGER
EW-18 Growth Inhibition Assay IC50=250.9 nM SANGER
MS-1 Growth Inhibition Assay IC50=252.53 nM SANGER
Calu-6 Growth Inhibition Assay IC50=253.55 nM SANGER
GR-ST Growth Inhibition Assay IC50=255.42 nM SANGER
GAK Growth Inhibition Assay IC50=256.91 nM SANGER
TE-9 Growth Inhibition Assay IC50=257.47 nM SANGER
HuH-7 Growth Inhibition Assay IC50=258.44 nM SANGER
KYSE-520 Growth Inhibition Assay IC50=260.77 nM SANGER
NCI-H520 Growth Inhibition Assay IC50=266.61 nM SANGER
HD-MY-Z Growth Inhibition Assay IC50=272.79 nM SANGER
SW756 Growth Inhibition Assay IC50=274.78 nM SANGER
NB12 Growth Inhibition Assay IC50=277.12 nM SANGER
EW-3 Growth Inhibition Assay IC50=279.89 nM SANGER
AM-38 Growth Inhibition Assay IC50=281.52 nM SANGER
NCI-H23 Growth Inhibition Assay IC50=283.92 nM SANGER
GOTO Growth Inhibition Assay IC50=285.56 nM SANGER
NCI-H1693 Growth Inhibition Assay IC50=290.32 nM SANGER
MOLT-16 Growth Inhibition Assay IC50=290.5 nM SANGER
HOP-92 Growth Inhibition Assay IC50=290.7 nM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=292.65 nM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=294.55 nM SANGER
CAL-54 Growth Inhibition Assay IC50=300.73 nM SANGER
D-263MG Growth Inhibition Assay IC50=305.52 nM SANGER
SKG-IIIa Growth Inhibition Assay IC50=311.14 nM SANGER
HAL-01 Growth Inhibition Assay IC50=313.44 nM SANGER
LAN-6 Growth Inhibition Assay IC50=315.11 nM SANGER
NCI-H1304 Growth Inhibition Assay IC50=321.17 nM SANGER
no-11 Growth Inhibition Assay IC50=321.64 nM SANGER
IST-MES1 Growth Inhibition Assay IC50=323.35 nM SANGER
L-363 Growth Inhibition Assay IC50=324.43 nM SANGER
EM-2 Growth Inhibition Assay IC50=325.41 nM SANGER
DV-90 Growth Inhibition Assay IC50=329.45 nM SANGER
Saos-2 Growth Inhibition Assay IC50=329.94 nM SANGER
UMC-11 Growth Inhibition Assay IC50=331.28 nM SANGER
Raji Growth Inhibition Assay IC50=334.64 nM SANGER
RXF393 Growth Inhibition Assay IC50=335.43 nM SANGER
EW-11 Growth Inhibition Assay IC50=341.56 nM SANGER
BL-70 Growth Inhibition Assay IC50=342.01 nM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=344.64 nM SANGER
LU-139 Growth Inhibition Assay IC50=344.92 nM SANGER
U-87-MG Growth Inhibition Assay IC50=346.04 nM SANGER
LU-65 Growth Inhibition Assay IC50=346.4 nM SANGER
U031 Growth Inhibition Assay IC50=353.87 nM SANGER
HN Growth Inhibition Assay IC50=354.27 nM SANGER
MHH-CAL-2 Growth Inhibition Assay IC50=359.21 nM SANGER
NCI-H510A Growth Inhibition Assay IC50=359.59 nM SANGER
NB5 Growth Inhibition Assay IC50=359.81 nM SANGER
KG-1 Growth Inhibition Assay IC50=361.52 nM SANGER
EFO-21 Growth Inhibition Assay IC50=361.85 nM SANGER
UACC-257 Growth Inhibition Assay IC50=362.05 nM SANGER
SW1417 Growth Inhibition Assay IC50=363.23 nM SANGER
NCI-H1417 Growth Inhibition Assay IC50=370.04 nM SANGER
DSH1 Growth Inhibition Assay IC50=372.72 nM SANGER
CAKI-1 Growth Inhibition Assay IC50=375.48 nM SANGER
SIMA Growth Inhibition Assay IC50=381.86 nM SANGER
LS-1034 Growth Inhibition Assay IC50=384.51 nM SANGER
K-562 Growth Inhibition Assay IC50=385.8 nM SANGER
LOXIMVI Growth Inhibition Assay IC50=389.19 nM SANGER
MC116 Growth Inhibition Assay IC50=391.41 nM SANGER
MPP-89 Growth Inhibition Assay IC50=392.94 nM SANGER
SN12C Growth Inhibition Assay IC50=394.87 nM SANGER
BHT-101 Growth Inhibition Assay IC50=395.92 nM SANGER
DMS-114 Growth Inhibition Assay IC50=396.31 nM SANGER
NCI-H1838 Growth Inhibition Assay IC50=405.05 nM SANGER
HT Growth Inhibition Assay IC50=405.15 nM SANGER
Caov-3 Growth Inhibition Assay IC50=406.19 nM SANGER
LB2518-MEL Growth Inhibition Assay IC50=413.1 nM SANGER
C3A Growth Inhibition Assay IC50=415.79 nM SANGER
NCI-H226 Growth Inhibition Assay IC50=416.64 nM SANGER
KMS-12-PE Growth Inhibition Assay IC50=418.06 nM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=425.05 nM SANGER
OE33 Growth Inhibition Assay IC50=426.02 nM SANGER
COLO-678 Growth Inhibition Assay IC50=427.18 nM SANGER
NCI-H1963 Growth Inhibition Assay IC50=430.11 nM SANGER
LAMA-84 Growth Inhibition Assay IC50=437.3 nM SANGER
NCI-H2171 Growth Inhibition Assay IC50=440.67 nM SANGER
U-266 Growth Inhibition Assay IC50=451.49 nM SANGER
SNU-C2B Growth Inhibition Assay IC50=460.97 nM SANGER
T47D Growth Inhibition Assay IC50=469.69 nM SANGER
TE-6 Growth Inhibition Assay IC50=469.81 nM SANGER
OVCAR-3 Growth Inhibition Assay IC50=470.41 nM SANGER
C-4-II Growth Inhibition Assay IC50=472.56 nM SANGER
EFM-19 Growth Inhibition Assay IC50=478.27 nM SANGER
NCI-N87 Growth Inhibition Assay IC50=479.92 nM SANGER
NCI-H187 Growth Inhibition Assay IC50=493.21 nM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=499.01 nM SANGER
OPM-2 Growth Inhibition Assay IC50=501.81 nM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=513.16 nM SANGER
RMG-I Growth Inhibition Assay IC50=513.98 nM SANGER
IST-SL1 Growth Inhibition Assay IC50=517.42 nM SANGER
UACC-893 Growth Inhibition Assay IC50=521.51 nM SANGER
Becker Growth Inhibition Assay IC50=521.83 nM SANGER
HPAF-II Growth Inhibition Assay IC50=527.24 nM SANGER
HCC1954 Growth Inhibition Assay IC50=540.83 nM SANGER
SNU-449 Growth Inhibition Assay IC50=548.01 nM SANGER
NCI-H1563 Growth Inhibition Assay IC50=556.49 nM SANGER
HDLM-2 Growth Inhibition Assay IC50=568.59 nM SANGER
NCI-H69 Growth Inhibition Assay IC50=568.8 nM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=570.15 nM SANGER
NCI-H1792 Growth Inhibition Assay IC50=572.43 nM SANGER
NCI-H2141 Growth Inhibition Assay IC50=573.69 nM SANGER
KMOE-2 Growth Inhibition Assay IC50=576.32 nM SANGER
NCI-H1155 Growth Inhibition Assay IC50=579.87 nM SANGER
LK-2 Growth Inhibition Assay IC50=581.07 nM SANGER
HCC1187 Growth Inhibition Assay IC50=591.47 nM SANGER
EGI-1 Growth Inhibition Assay IC50=598.27 nM SANGER
NCI-H1623 Growth Inhibition Assay IC50=604.6 nM SANGER
MN-60 Growth Inhibition Assay IC50=605.37 nM SANGER
JAR Growth Inhibition Assay IC50=625.95 nM SANGER
HCC1419 Growth Inhibition Assay IC50=631.74 nM SANGER
LU-165 Growth Inhibition Assay IC50=639.4 nM SANGER
TYK-nu Growth Inhibition Assay IC50=662.55 nM SANGER
DG-75 Growth Inhibition Assay IC50=665.83 nM SANGER
PFSK-1 Growth Inhibition Assay IC50=678.08 nM SANGER
MKN7 Growth Inhibition Assay IC50=689.95 nM SANGER
DMS-153 Growth Inhibition Assay IC50=698.15 nM SANGER
HTC-C3 Growth Inhibition Assay IC50=703.94 nM SANGER
GCIY Growth Inhibition Assay IC50=725.12 nM SANGER
NCI-H1092 Growth Inhibition Assay IC50=737.95 nM SANGER
EB-3 Growth Inhibition Assay IC50=771.02 nM SANGER
CAL-120 Growth Inhibition Assay IC50=777.52 nM SANGER
BT-474 Growth Inhibition Assay IC50=778.81 nM SANGER
L-428 Growth Inhibition Assay IC50=790.9 nM SANGER
Mo-T Growth Inhibition Assay IC50=804.65 nM SANGER
CAL-72 Growth Inhibition Assay IC50=840.67 nM SANGER
AsPC-1 Growth Inhibition Assay IC50=855.26 nM SANGER
U-118-MG Growth Inhibition Assay IC50=856.34 nM SANGER
GCT Growth Inhibition Assay IC50=861.48 nM SANGER
EKVX Growth Inhibition Assay IC50=871.87 nM SANGER
NCI-H1755 Growth Inhibition Assay IC50=873.52 nM SANGER
Capan-2 Growth Inhibition Assay IC50=898.11 nM SANGER
NCI-H1793 Growth Inhibition Assay IC50=900.87 nM SANGER
PLC-PRF-5 Growth Inhibition Assay IC50=901.35 nM SANGER
M14 Growth Inhibition Assay IC50=905.27 nM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=914.35 nM SANGER
SK-MM-2 Growth Inhibition Assay IC50=942.3 nM SANGER
PC-3 Growth Inhibition Assay IC50=957.22 nM SANGER
EW-24 Growth Inhibition Assay IC50=970.4 nM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=971.53 nM SANGER
NCI-H1581 Growth Inhibition Assay IC50=981.31 nM SANGER
THP-1 Growth Inhibition Assay IC50=989.42 nM SANGER
NCI-H1993 Growth Inhibition Assay IC50=1.00076 μM SANGER
DOK Growth Inhibition Assay IC50=1.01762 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=1.019 μM SANGER
YT Growth Inhibition Assay IC50=1.04568 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=1.06036 μM SANGER
TCCSUP Growth Inhibition Assay IC50=1.23083 μM SANGER
BEN Growth Inhibition Assay IC50=1.23742 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=1.26763 μM SANGER
COLO-829 Growth Inhibition Assay IC50=1.2748 μM SANGER
UACC-62 Growth Inhibition Assay IC50=1.32145 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=1.33771 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=1.34337 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=1.37129 μM SANGER
RL Growth Inhibition Assay IC50=1.42066 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=1.43159 μM SANGER
TGW Growth Inhibition Assay IC50=1.45942 μM SANGER
HT55 Growth Inhibition Assay IC50=1.47168 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=1.47841 μM SANGER
KY821 Growth Inhibition Assay IC50=1.49429 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=1.53055 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=1.57026 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=1.61711 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=1.63084 μM SANGER
D-542MG Growth Inhibition Assay IC50=1.65305 μM SANGER
LC-1F Growth Inhibition Assay IC50=1.66203 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=1.66343 μM SANGER
MFE-280 Growth Inhibition Assay IC50=1.66812 μM SANGER
S-117 Growth Inhibition Assay IC50=1.70504 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=1.71733 μM SANGER
BT-20 Growth Inhibition Assay IC50=1.74068 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=1.74078 μM SANGER
CaR-1 Growth Inhibition Assay IC50=1.78324 μM SANGER
LN-405 Growth Inhibition Assay IC50=1.80143 μM SANGER
RT4 Growth Inhibition Assay IC50=1.84417 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=1.93886 μM SANGER
SW1463 Growth Inhibition Assay IC50=1.95701 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=2.00624 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=2.01767 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=2.01782 μM SANGER
HCC70 Growth Inhibition Assay IC50=2.05463 μM SANGER
SW1088 Growth Inhibition Assay IC50=2.06931 μM SANGER
NB6 Growth Inhibition Assay IC50=2.185 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=2.26917 μM SANGER
A704 Growth Inhibition Assay IC50=2.29135 μM SANGER
EVSA-T Growth Inhibition Assay IC50=2.30089 μM SANGER
HCT-15 Growth Inhibition Assay IC50=2.35466 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=2.36583 μM SANGER
GMS-10 Growth Inhibition Assay IC50=2.39738 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=2.41429 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=2.51328 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=2.56592 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=2.73015 μM SANGER
T98G Growth Inhibition Assay IC50=2.80401 μM SANGER
DMS-79 Growth Inhibition Assay IC50=2.90988 μM SANGER
SNU-475 Growth Inhibition Assay IC50=2.92572 μM SANGER
COLO-792 Growth Inhibition Assay IC50=3.0287 μM SANGER
YAPC Growth Inhibition Assay IC50=3.32832 μM SANGER
UACC-812 Growth Inhibition Assay IC50=3.33738 μM SANGER
Mewo Growth Inhibition Assay IC50=3.46086 μM SANGER
COLO-824 Growth Inhibition Assay IC50=3.57378 μM SANGER
SCC-9 Growth Inhibition Assay IC50=3.91309 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=3.98703 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=4.01174 μM SANGER
COR-L88 Growth Inhibition Assay IC50=4.3958 μM SANGER
RCM-1 Growth Inhibition Assay IC50=4.49272 μM SANGER
JVM-3 Growth Inhibition Assay IC50=4.60618 μM SANGER
ECC4 Growth Inhibition Assay IC50=4.76541 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=4.85134 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=5.22877 μM SANGER
D-502MG Growth Inhibition Assay IC50=5.24262 μM SANGER
NCI-H2227 Growth Inhibition Assay IC50=5.36231 μM SANGER
DMS-53 Growth Inhibition Assay IC50=6.17106 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=6.46806 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=7.41791 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=7.57303 μM SANGER
TALL-1 Growth Inhibition Assay IC50=7.9688 μM SANGER
HCC1395 Growth Inhibition Assay IC50=8.15122 μM SANGER
EFE-184 Growth Inhibition Assay IC50=8.37216 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=8.68686 μM SANGER
TT Growth Inhibition Assay IC50=9.06966 μM SANGER
U-2-OS Growth Inhibition Assay IC50=9.81393 μM SANGER
SHP-77 Growth Inhibition Assay IC50=9.9029 μM SANGER
HCC1143 Growth Inhibition Assay IC50=10.4797 μM SANGER
A498 Growth Inhibition Assay IC50=18.2976 μM SANGER
LS-513 Growth Inhibition Assay IC50=18.6093 μM SANGER
K052 Growth Inhibition Assay IC50=21.4418 μM SANGER
SiHa Growth Inhibition Assay IC50=23.3371 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=30.0611 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=31.1836 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=32.4175 μM SANGER
C32 Growth Inhibition Assay IC50=32.872 μM SANGER
SW684 Growth Inhibition Assay IC50=34.1561 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=35.5377 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=36.7547 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=41.9726 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=44.3284 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=48.8248 μM SANGER
Klicken Sie hier, um weitere experimentelle Daten zu Zelllinien anzuzeigen

Chemische Informationen, Lagerung & Stabilität

Molekulargewicht 579.98 Formel

C27H29NO11.HCl

 Lagerung (Ab dem Eingangsdatum)
CAS-Nr. 25316-40-9 SDF herunterladen Lagerung von Stammlösungen

Synonyme Adriamycin, NSC 123127, Hydroxydaunorubicin HCl Smiles CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl

Löslichkeit

In vitro
Charge:

DMSO : 100 mg/mL (172.41 mM)
(Feuchtigkeitskontaminiertes DMSO kann die Löslichkeit verringern. Verwenden Sie frisches, wasserfreies DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

Molaritätsrechner

Masse Konzentration Volumen Molekulargewicht
Verdünnungsrechner Molekulargewichtsrechner

In vivo
Charge:

In-vivo-Formulierungsrechner (Klare Lösung)

Schritt 1: Geben Sie die untenstehenden Informationen ein (Empfohlen: Ein zusätzliches Tier zur Berücksichtigung von Verlusten während des Experiments)

mg/kg g μL

Schritt 2: Geben Sie die In-vivo-Formulierung ein (Dies ist nur der Rechner, keine Formulierung. Bitte kontaktieren Sie uns zuerst, wenn es im Abschnitt "Löslichkeit" keine In-vivo-Formulierung gibt.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Berechnungsergebnisse:

Arbeitskonzentration: mg/ml;

Methode zur Herstellung der DMSO-Stammlösung: mg Wirkstoff vorgelöst in μL DMSO ( Konzentration der Stammlösung mg/mL, Bitte kontaktieren Sie uns zuerst, wenn die Konzentration die DMSO-Löslichkeit der Wirkstoffcharge überschreitet. )

Methode zur Herstellung der In-vivo-Formulierung: Nehmen Sie μL DMSO Stammlösung, dann hinzufügenμL PEG300, mischen und klären, dann hinzufügenμL Tween 80, mischen und klären, dann hinzufügen μL ddH2O, mischen und klären.

Methode zur Herstellung der In-vivo-Formulierung: Nehmen Sie μL DMSO Stammlösung, dann hinzufügen μL Maisöl, mischen und klären.

Hinweis: 1. Bitte stellen Sie sicher, dass die Flüssigkeit klar ist, bevor Sie das nächste Lösungsmittel hinzufügen.
2. Achten Sie darauf, das/die Lösungsmittel der Reihe nach hinzuzufügen. Sie müssen sicherstellen, dass die bei der vorherigen Zugabe erhaltene Lösung eine klare Lösung ist, bevor Sie mit der Zugabe des nächsten Lösungsmittels fortfahren. Physikalische Methoden wie Vortex, Ultraschall oder ein heißes Wasserbad können zur Unterstützung des Lösens verwendet werden.

Wirkmechanismus

Targets/IC50/Ki
AMPK
Topo II
(Tumor cells)
In vitro

Doxorubicin, ein antibiotisches Anthrazyklin, wird üblicherweise als eine Substanz angesehen, die ihre Antitumoraktivität auf zwei grundlegenden Ebenen ausübt: Es verändert die DNA und produziert freie Radikale, um die Apoptose von Krebszellen durch DNA-Schäden auszulösen. Doxorubicin kann die DNA-Synthese blockieren, indem es in den DNA-Strang interkaliert, und hemmt die DNA Topoisomerase II (TOP2). Doxorubicin ist am wirksamsten, wenn Zellen sich schnell vermehren und hohe Mengen an TOP2 exprimieren. Zusätzlich kann Doxorubicin die Apoptose auslösen, indem es Ceramid produziert (das die Apoptose durch Aktivierung von p53 oder anderen nachgeschalteten Signalwegen wie JNK fördert), den Abbau von Akt durch Serin-Threonin-Proteasen, die mitochondriale Freisetzung von Cytochrom c, eine erhöhte FasL (Todesrezeptor Fas/CD95-Ligand) mRNA-Produktion und eine größere Produktion freier Radikale bewirkt.

Eine Vorbehandlung mit GSNO (Nitrosoglutathion) unterdrückt die Resistenz in der Doxorubicin-resistenten Brustkrebszelllinie MCF7/Dx, begleitet von einer verstärkten Proteinglutathionylierung und Akkumulation von Doxorubicin im Zellkern.

Doxorubicin-induzierter G2/M-Checkpoint-Arrest wird auf eine erhöhte Cyclin G2 (CycG2)-Expression und Phospho-Modifikation von Proteinen in den Signalwegen der Ataxia telangiectasia mutated (ATM) und ATM and Rad3-related (ATR) zurückgeführt.

Doxorubicin hemmt die AMP-aktivierte Proteinkinase (AMPK), was zu einer SIRT1-Dysfunktion, p53-Akkumulation und einem erhöhten Zelltod in embryonalen Mäusefibroblasten (MEFs) und Kardiomyozyten führt, die durch eine Vorhemmung von AMPK weiter sensibilisiert werden können.

Doxorubicin löst eine ausgeprägte Hitzeschockreaktion aus, und entweder die Hemmung oder das Silencing von Hitzeschockproteinen verstärkt den Doxorubicin-apoptotischen Effekt in Neuroblastomzellen. Eine nanomolare Doxorubicin-Behandlung von Neuroblastomzellen verursacht eine dosisabhängige Über-Ubiquitinierung eines spezifischen Satzes von Proteinen in Abwesenheit einer messbaren Hemmung des Proteasoms und einen Aktivitätsverlust von ubiquitinierten Enzymen wie Laktatdehydrogenase und α-Enolase, deren Protein-Ubiquitinierungsmuster denen von Proteasom-Inhibitoren ähneln, was darauf hindeutet, dass Doxorubicin seine Wirkung auch durch Schädigung von Proteinen ausüben kann.

In vivo

In vivo hat Doxorubicin in Kombination mit adenoviralem MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) den größten Effekt bei der Verringerung der Volumina von MB231-Tumoren und der Verlängerung des Überlebens von Mäusen.

Obwohl sein Einsatz durch die chronischen und akuten toxischen Nebenwirkungen begrenzt ist, ist Doxorubicin bei der Behandlung von Brust- und Ösophaguskarzinomen, soliden Tumoren im Kindesalter, Osteosarkomen, Kaposi-Sarkom, Weichteilsarkomen sowie Hodgkin- und Non-Hodgkin-Lymphomen unverzichtbar.

Literatur
  • [4] https://pubmed.ncbi.nlm.nih.gov/21364585/
  • [5] https://pubmed.ncbi.nlm.nih.gov/22589537/
  • [6] https://pubmed.ncbi.nlm.nih.gov/22267730/
  • [7] https://pubmed.ncbi.nlm.nih.gov/22374332/
  • [8] https://pubmed.ncbi.nlm.nih.gov/22536838/
  • [9] https://pubmed.ncbi.nlm.nih.gov/19377506/
  • [10] https://pubmed.ncbi.nlm.nih.gov/17194596/
  • [11] https://pubmed.ncbi.nlm.nih.gov/17194596/

Anwendungen

Methoden Biomarker Bilder PMID
Western blot POU5F1 / SOX2 / NANOG ATG5 / ATG7 / SQSTM1 / LC3A-II / LC3B-II / p-mTOR P62 / LC3II p-AKT(T308) / p-Akt(S473) / Akt / p-PRAS40(T246) / PRAS40 / p-H2A.X(S139)
S1208-WB1
27929731
Growth inhibition assay Cell viability
S1208-viability1
25871400
Immunofluorescence LC3
S1208-IF1
24970805
ELISA OPN
S1208-ELISA1
24963635

Klinische Studieninformationen

(Daten von https://clinicaltrials.gov, aktualisiert am 2024-05-22)

NCT-Nummer Rekrutierung Erkrankungen Sponsor/Kooperationspartner Startdatum Phasen
NCT06186700 Active not recruiting
Breast Cancer Female
Mansoura University
 December 25 2023 Phase 2
NCT05567601 Not yet recruiting
Ovarian Cancer|AIDS-related Kaposi Sarcoma|Multiple Myeloma|Metastatic Breast Cancer
Baxter Healthcare Corporation
 November 30 2023 Phase 1
NCT06088290 Recruiting
Leiomyosarcoma
PharmaMar
 September 21 2023 Phase 2|Phase 3
NCT05748834 Recruiting
Breast Cancer
SCRI Development Innovations LLC|Seagen Inc.
 July 24 2023 Phase 2
NCT05853120 Recruiting
Sexually Transmitted Diseases
Emory University|Centers for Disease Control and Prevention
 May 31 2023 Phase 4

Technischer Support

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Häufig gestellte Fragen

Frage 1:
Why did the IC50 of it vary over time in our measurement?

Antwort:
Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of it, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.